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Grubova, I.Y. |
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Title |
Density functional theory study of interface interactions in hydroxyapatite/rutile composites for biomedical applications |
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Doctoral thesis |
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2018 |
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251 p. |
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Doctoral thesis; Engineering sciences. Technology; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT) |
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UA @ admin @ c:irua:158087 |
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7760 |
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Author |
van Walsem, J. |
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Title |
Design and optimization of a photocatalytic reactor for air purification in ventilation systems |
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Doctoral thesis |
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Year |
2019 |
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158 p. |
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Doctoral thesis; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Photocatalysis has been labeled for decades as a promising technique for air purification. The principle seems straightforward and requires a photocatalyst that is immobilized on a substrate, and one or more UV sources to activate the photocatalyst. No waste products are produced, the reactions occur in mild conditions and the supplies are relatively cheap. Yet it seems that the commercialization of photocatalytic systems does not break through on the global market. The aim of this thesis is to identify and tackle the bottlenecks that impede commercialization from an application-oriented approach. The problem of indoor air pollution is enhanced by the fact that people spend more and more time indoors and that ventilation is kept to a minimum as an energy-saving measure. This inevitably leads to an accumulation of volatile organic compounds (VOCs) that are emitted by e.g. building materials, paint and furniture. Human exposure to VOCs is directly related to the sick building syndrome leading to complaints such as headache, fatigue, dizziness and lack of concentration. In addition, exposure to VOCs is related to serious long-term health effects such as cancer or respiratory diseases. Therefore, significant research efforts are focused on advanced indoor air purification methods. Integration or retrofitting of a photocatalytic (PCO) air purifying unit into heating, ventilation and air conditioning (HVAC) equipment has been chosen as an interesting approach. As a starting point of this thesis, the operational conditions of a ventilation system were mapped. These systems are characterized by high flow rates and the necessity of minimal pressure losses. Pressure losses increase the energy demand and can lead to failure of the ventilation fan and thereby undermine the proper functioning of the ventilation system. A suitable substrate must allow the contaminated air to pass through with a minimal pressure drop, allow sufficient contact time between VOC and photocatalyst, have a large surface area available for coating with excellent adhesion, and be transparent to UV light. Therefore, the permeability and the available exposed surface were selected as main selection criteria. After a thorough quantitative analysis of potential substrates, borosilicate glass tubes were selected. Glass tubes can easily be stacked to constitute a transparent monolithic multi-tube reactor, with their length parallel to the air flow in order to minimize the pressure drop. Moreover, borosilicate glass is relatively inexpensive and has excellent UV-A light transmitting properties. Based on a literature study, a sol-gel coating procedure was selected that is extremely suitable for coating glass substrates. The next step was to optimize the amount of P25 (commercial titanium dioxide) in the photocatalytic sol-gel coating for its application. More P25 in the sol-gel coating results in a higher adsorption capacity and consequently a higher photocatalytic activity, but greatly reduces the transparency of the coating. After an in-depth study, the concentration of 10 g L-1 P25 was selected as the most feasible for multi-tube reactors. Since the operation of photocatalytic reactors is based on a complex interaction of physical and chemical processes, mathematical models were developed, supported by experimental data, that include all these phenomena as a tool for reactor design and optimization. By making use of such models, time-consuming and expensive experimental research can be minimized. However, the experimental validation of models is of utmost importance to prove its reliability and accuracy. Intrinsic kinetic parameters provide the fundamentals for these models as they describe the photocatalytic reaction rate, independent of fluid dynamics, reactor geometry and radiation field. In this work they were estimated by means of a Computational Fluid Dynamics (CFD) study, based on FTIR (Fourier-transform infrared spectroscopy) experiments with a lab scale multi-tube reactor. The kinetic parameters were validated by an alternative analytic approach, emphasizing the accuracy and reliability of the simulations. Finally, the aforementioned CFD approach, based on the simultaneously modelling of airflow, mass transfer, UV light irradiation and photocatalytic reactions, was used to obtain insights for the light source configuration in upscaled multi-tube reactors. After taking all these insights and some practical implications into account, a final upscaled multi-tube reactor design was proposed and converted into a first built prototype. Subsequently, it was evaluated according the CEN-EN-16486-1 standard for VOC removal by the external scientific research center ‘CERTECH’. The scientific results, regarding the mineralization of the VOCs and photocatalytic efficiency of the reactor, demonstrated the feasibility for indoor air purification by the upscaled multi-tube reactor and the possible implementation in ventilation systems. |
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UA @ admin @ c:irua:160205 |
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7763 |
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Author |
Voordeckers, D. |
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Title |
Design to breathe : understanding and altering wind patterns in street canyons to reduce human exposure to air pollution |
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Doctoral thesis |
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Year |
2023 |
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xxii, 303 p. |
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Doctoral thesis; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL); Research Group for Urban Development; Intelligence in PRocesses, Advanced Catalysts and Solvents (iPRACS) |
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Air pollution is proclaimed by the World Health Organiaation (WHO) as the biggest environmental threat to human health. Street canyons, or urban roads flanked by a continuous row of high buildings on both sides, are perceived as typical bottleneck areas for air quality due to their lack of natural ventilation. This doctoral thesis aims to integrate expert knowledge on in-canyon flow fields and pollution dispersion in street canyons from the specialized field of (bio)engineering into the field of urban planning and vice versa. In Chapter 1, a Geospatial Information System (GIS) method was developed to detect exposure zones and hotspot street canyons. A critical combination between aspect ratio (AR > 0.65) and traffic volume (TVmax > 300) was detected and subsequently used to detect hotspot street canyons in three major European cities (Antwerp, London and Paris). Chapter 2 focusses on acquiring in-depth knowledge on flow and concentration fields in street canyons by conducting an extensive literature review on over 200 studies and translates this knowledge into nineteen guidelines and eleven spatial tools, comprised in a toolbox for urban planning. Subsequently, computational fluid dynamics (CFD) was used into a research trough design process (Chapter 4) to illustrate how the design tools can be applied to a specific case study (Belgiëlei, Antwerp). Alternations to traffic lanes (traffic lane reduction and lateral displacement) combined with low boundary walls (LBWs), were found to reduce NO2 levels in the entire pedestrian area up to – 3.6 % and peak pollutions were reduced by -8 %. A maximum NO2 reduction was reached by combining a traffic lane displacement with hedges, adjustments to the tree planting pattern and an increased ground-level permeability, leading to reductions up to – 4.5 % in the pedestrian areas. In conclusion, urban design was found to be a valuable tool to enhance the effect of emission reduction strategies and draw in-canyon concentrations closer to the value of the background concentration. However, the background concentration seemed to dominate the efficiency of the urban design interventions and therefore, additional measures should be taken to reduce background pollution levels. This dissertation aims to contribute to the awareness of air pollution in street canyons, as well as support local governments in taking action by delivering spatial tools and guidelines applicable for urban planning and represents a framework for the dissemination of expert information on air quality in street canyons to the field of urban planning. |
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Most recent IF: NA |
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Call Number |
UA @ admin @ c:irua:196399 |
Serial |
7767 |
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Author |
Otten, P.; Rajsic, S.; Van Grieken, R. |
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Title |
Detection of ammomium compounds at the single particle level |
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P3 Proceeding |
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Year |
1987 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:117520 |
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7773 |
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Godoi, A.F.L.; Sawada, E.Y.; de Marchi, M.R.R.; Van Grieken, R.; Godoi, R.H.M. |
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Title |
Determination of BTEX by GCMS in air of offset printing plants: comparison between conventional and ecological inks |
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A3 Journal article |
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Year |
2009 |
Publication |
Water, air, and soil pollution : focus |
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9 |
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3/4 |
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163-169 |
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A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Abstract |
The use of inks containing organic solvents by the offset printing process implies in the release of volatile organic compounds to the work environment. Many of these compounds such as benzene, toluene, ethylbenzene, and the xylene isomers (well known by the acronym BTEX) are extremely toxic. In this study, the BTEX concentrations were determined in two different printing plants that use distinct types of inks: the conventional and the so-called ecological, which is manufactured based on vegetal oil. Concentration ranges were 4384, 153,480, 2133, 5459, and 2236 μg m−3 for benzene, toluene, ethylbenzene, m + p-xylene, and o-xylene, respectively, for the conventional printing plant. At the ecological printing plant, concentration ranges were below limit of detection (<LD)-31, <LD-618, <LD-1,690, <LD-10,500, <LD-3,360 μg m−3 for benzene, toluene, ethylbenzene, m + p-xylene, and o-xylene, respectively. BTEX concentrations are lower at the ecological printing environment than in the conventional, where mineral oil-based inks are used. However, the worker who cleans the printing matrices is exposed to high concentrations of ethylbenzene and xylenes, due probably to the cleaning products composition (containing high amounts of BTEX). Although the BTEX concentrations found in both printing work environments were below the limits considered by the Brazilian Law for Activities and Unhealthy Operations (NR-15), the exposure to such vapors characterizes risk to the workers health for some of the evaluated samples, mainly the personal ones. |
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2009-09-29 |
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1567-7230 |
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Call Number |
UA @ admin @ c:irua:80493 |
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7775 |
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Author |
Schmeling, M.; Van Grieken, R. |
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Determination of light elements in marine aerosols by grazing-emission X-ray fluorescence |
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P3 Proceeding |
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1999 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:27596 |
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7781 |
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Muia, L.M.; Van Grieken, R. |
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Determination of rare earth elements in geological materials by total reflection X-ray fluorescence |
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A1 Journal article |
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1991 |
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Analytica chimica acta |
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251 |
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177-181 |
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A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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0003-2670; 1873-4324 |
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UA @ admin @ c:irua:663 |
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7786 |
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Bencs, L.; Ravindra, K.; Van Grieken, R. |
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Determination of ultra-trace levels of palladium in environenmental samples by graphite furnace atomic spectrometry techniques |
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H3 Book chapter |
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2006 |
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173-189
T2 - Palladium emissions in the environmen |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:54921 |
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7795 |
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Author |
Semlali, B.-eddine B.; El Amrani, C.; Denys, S. |
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Development of a Java-based application for environmental remote sensing data processing |
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A1 Journal article |
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2019 |
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International Journal of Electrical and Computer Engineering |
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9 |
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3 |
Pages |
1978-1986 |
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A1 Journal article; Sustainable Energy, Air and Water Technology (DuEL) |
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Air pollution is one of the most serious problems the world faces today. It is highly necessary to monitor pollutants in real-time to anticipate and reduce damages caused in several fields of activities. Likewise, it is necessary to provide decision makers with useful and updated environmental data. As a solution to a part of the above-mentioned necessities, we developed a Java-based application software to collect, process and visualize several environmental and pollution data, acquired from the Mediterranean Dialog earth Observatory (MDEO) platform [1]. This application will amass data of Morocco area from EUMETSAT satellites, and will decompress, filter and classify the received datasets. Then we will use the processed data to build an interactive environmental real-time map of Morocco. This should help finding out potential correlations between pollutants and emitting sources. |
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2019-04-20 |
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2088-8708 |
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UA @ admin @ c:irua:163847 |
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7799 |
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Author |
Hauchecorne, B. |
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Development of an FTIR in situ reactor for real time study of surface reactions in photocatalysis |
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Doctoral thesis |
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2011 |
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155 p. |
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Doctoral thesis; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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978-90-5728-335-2 |
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UA @ admin @ c:irua:89854 |
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7801 |
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Pilehvar, S. |
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Development of new strategies for electrochemical aptasensing |
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Doctoral thesis |
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2016 |
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198 p. |
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Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:133790 |
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7802 |
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Author |
Alfeld, M.W. |
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Development of scanning macr-XRF for the investigation of historical paintings |
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Doctoral thesis |
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2013 |
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264 p. |
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Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:111339 |
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7803 |
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Author |
Blidar, A.-M. |
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The development of sensitive and selective electrochemical methods for the detection of antibiotics |
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Doctoral thesis |
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2021 |
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Abbreviated Journal |
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139 p. |
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Doctoral thesis; Pharmacology. Therapy; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Antwerp Electrochemical and Analytical Sciences Lab (A-Sense Lab) |
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Abstract |
The discovery of antibiotics represented one of the greatest breakthroughs in medicine. Their success combined with an increasing intensive use is apparently bound to be also their undoing. This is due to the development of acquired antibiotic resistance, leading to inefficient antibiotherapy and even to the impossibility of treatment and death. The development and spread of antibiotic resistance are fueled by the widespread presence of trace levels of antibiotics residue, in various media, from environment to aliments. One of the solutions is the rigorous monitoring of the levels of antibiotics, which in term requires an almost constant development of new, more accessible analytical methods, especially screening methods, capable of decentralized analysis. In this direction, the electrochemical detection of antibiotics represents a very viable alternative. In this context, the aim of this thesis was to develop new electrochemical methods for the detection of antibiotics by employing and expanding on several strategies, like biomimetic sensors and electrochemical fingerprinting. Five studies were described in this thesis, that can be roughly divided in three categories, based on the analytical strategy employed. The first group is represented by direct electrochemical methods. The second group focuses on the use of biomimetic elements, molecularly imprinted polymers and aptamers. The hyphenation of electrochemical methods with other analytical methods was explored in the last group. In the last study, included in this group, the singlet oxygen-based photoelectrochemical approach was used for the detection of a phenolic antibiotic, rifampicin. The originality of the thesis consists in the testing and development of new approaches to various strategies used in electrochemical detection, revealing new insights in the field of electrochemical detection of antibiotics. The complex electrochemical fingerprint and the mechanism of the electrochemical oxidation were created and investigated, respectively, for the antibiotic vancomycin. New sensitive nanoplatforms were prepared by employing and combining new protocols. Additionally, important contributions were brought through the study involving the singlet oxygen-based detection of rifampicin. We demonstrated how a photocatalyst can exhibit analyte selectivity by strongly interacting with a complex phenolic compound, rifampicin. Summing up, the studies presented in this thesis will have an important impact in the field of electrochemical detection of antibiotics. |
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Most recent IF: NA |
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Call Number |
UA @ admin @ c:irua:182955 |
Serial |
7804 |
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| Permanent link to this record |
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Author |
Bruynseels, F.; Van Grieken, R. |
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Title |
Direct detection of sulfate and nitrate layers on sampled marine aerosols by laser microprobe mass analysis |
Type |
A1 Journal article |
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Year |
1985 |
Publication |
Atmospheric environment |
Abbreviated Journal |
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Volume |
19 |
Issue |
11 |
Pages |
1969-1970 |
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Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Abstract |
The direct detection of sulfate and nitrate layers on sampled marine aerosols was carried out by laser microprobe mass analysts. |
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2003-08-06 |
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ISSN |
0004-6981 |
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Call Number |
UA @ admin @ c:irua:113617 |
Serial |
7810 |
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| Permanent link to this record |
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Author |
Eisma, D.; Kalf, J.; Karmini, M.; Mook, W.G.; Van Put, A.; Bernard, P.; Van Grieken, R. |
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Title |
Dispersal of suspended matter in Makasar Strait and the Flores Basin |
Type |
A1 Journal article |
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Year |
1989 |
Publication |
Netherlands journal of sea research |
Abbreviated Journal |
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Volume |
24 |
Issue |
4 |
Pages |
383-398 |
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Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Abstract |
In November 1984 in Makasar and the Flores Basin water samples were collected (T, S, dissolved O2, total CO2), bottom samples (sediment composition) and suspended matter (particle composition, particle size). A sediment trap was moored in the Flores Basin at 4600 m depth for nearly four months, covering the dry season. In the Flores Basin there are indications for bottom flow resuspending bottom material or preventing suspended material from settling; in Makasar Strait there is probably inflow of deep water both from the south and from the north, resulting in a very slow bottom water flor. Bottom deposits in Makasar Strait and the Flores Basin are predominantly terrigenous, with an admixture of organic carbonate and silica (mostly coccoliths). Volcanic material is primarily present near to the volcanoes in the south and reaches the deeper basins by slumping. In the suspended matter no volcanic particles and little planktonic material were found, although the latter form 10 to 15% of the top sediment and of the material deposited in the sediment trap. In suspension particles with a large concentration of tin (Sn) were found associated mainly with iron. They probably come from northern Kalimantan or northern Sulawesi. Suspended matter concentrations were mainly less than 0.5 mg·dm−3, only off the Mahakam river mouth were concentrations higher than 1 mg·dm−3. Particle size was erratic because of the variable composition of the coarser particles in suspension. Organic matter concentrations in suspension (in mg·dm−3) roughly follow the distribution of total suspended matter but organic content (in %) of the suspended matter does not show any trends. All organic matter in suspension is of marine origin except in the Mahakam river and estuary. Deposition rates, as estimated from the sediment trap results, are 150 mg·cm−2·a−1 for the total sediment, 26 mg·cm−2·a−1 for carbonate and 13 mg·cm−2·a−1 for organic matter. Flocs and fibres in suspension were only found in and below the Mahakam river plume that reaches ca 400 km from the river mouth to the southeast, and in surface waters associated with plankton (diatoms). The formation of these flocs (broken-up macroflocs or marine snow) is primarily related to particle concentration, turbulence, and the presence of organisms that produce sticky material or glue particles together. |
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2003-08-07 |
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ISSN |
0077-7579; 1873-1406 |
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no |
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Call Number |
UA @ admin @ c:irua:116825 |
Serial |
7814 |
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Author |
Van Grieken, R. |
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Title |
Dispersion of heavy metals |
Type |
H3 Book chapter |
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Year |
1998 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
319-324
T2 - Report on the environment and nature |
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Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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Call Number |
UA @ admin @ c:irua:22777 |
Serial |
7816 |
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Author |
Eisma, D.; van Put, A.; Van Grieken, R. |
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Title |
Distribution and composition of suspended matter around Sumbawa Island, Indonesia |
Type |
A3 Journal article |
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Year |
1992 |
Publication |
Mitteilungen aus dem Geologisch-Paläontologischen Institut der Universität Hamburg |
Abbreviated Journal |
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Volume |
70 |
Issue |
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Pages |
137-147 |
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Keywords |
A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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ISSN |
0072-1115 |
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no |
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Call Number |
UA @ admin @ c:irua:2849 |
Serial |
7817 |
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Author |
Rutten, I.; Safdar, S.; Ven, K.; Daems, D.; Spasic, D.; Lammertyn, J. |
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Title |
A DNA nanotechnology toolbox for mix-and-match biosensor design |
Type |
P3 Proceeding |
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Year |
2019 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
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Keywords |
P3 Proceeding; Engineering sciences. Technology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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Call Number |
UA @ admin @ c:irua:166107 |
Serial |
7819 |
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Author |
Janssen, E.; Kontozova-Deutsch, V.; Krupińska, B.; Moris, H.; Peckstadt, A.; van Bos, M.; Watteeuw, L.; Van Grieken, R. |
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Title |
Do gaseous pollutants and particulate matter endanger our world heritage? A study in the Museum Plantin-Moretus, Antwerp |
Type |
P3 Proceeding |
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Year |
2010 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
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Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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Call Number |
UA @ admin @ c:irua:85520 |
Serial |
7820 |
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Author |
Muhammad, S.; Wuyts, K.; De Wael, K.; Samson, R. |
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Title |
Does leaf micro-morphology influence the recognition of particles on SEM images? |
Type |
A3 Journal article |
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Year |
2021 |
Publication |
International Journal of Environmental Pollution and Remediation |
Abbreviated Journal |
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Volume |
9 |
Issue |
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Pages |
22-37 |
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Keywords |
A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Antwerp Electrochemical and Analytical Sciences Lab (A-Sense Lab) |
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Abstract |
Scanning electron microscopy (SEM) remains a popular approach to determine the shape, size, density and elemental composition of particles collected on leaf surfaces, but the effect of leaf micro-morphology on particle counts is not very well known. In this study, leaves of sixteen urban plant species were examined for particle density in June and September 2016 using SEM. The investigated plant species differed in leaf micro-morphology involving trichomes, raised stomata, epicuticular wax crystals and convex epidermal cells forming deep grooves between cells. The particle density on leaves of the investigated plant species was estimated by particle size fraction and leaf side. Particle density was significantly higher on the adaxial (AD) leaf side compared to the abaxial (AB) leaf side and higher for fine-particles than coarse-particles. The effect of trichome density on particle density of the AB and the AD leaf side was indicated to be significant and positive for both coarse and fine-particles in June but not in September. The successive repeated measurements elucidated that features constructing the topography of a leaf surface such as trichomes, stomata, and epidermal cells frequently contributed towards the edge enhancement effect, resulting in exaggerated particle counts. Besides, the mechanical drift contributed to the disparity in particle density measurements. Lastly, the reduction in particle density between successive measurements were imputed on the charging effect. These results enable us to suggest that in addition to characterization of micro-morphological features on a leaf surface, SEM will continue to be a useful approach for determining the particle: shape, size, elemental composition and density of the deposited particles. Nonetheless, the disparity in particle density measurements can occur due to abnormal particle recognition. Based on the results of September, we recommend that within-session successive repeated measurements (~ n ≥ 5) need to be performed to remove measurement uncertainties and obtain reliable quantitative data of particle counts using SEM. |
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Publication Date |
2021-09-15 |
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Open Access |
OpenAccess |
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Notes |
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Approved |
Most recent IF: NA |
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Call Number |
UA @ admin @ c:irua:181797 |
Serial |
7822 |
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| Permanent link to this record |
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Author |
Verbueken, A.H.; Jacob, W.A.; Frederik, P.M.; Busing, W.M.; Hersten, R.C.; Van Grieken, R.E. |
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Title |
Doped albumin : stndardization possibilities for LAMMA-analysis of thin freeze-dried cryosections of biological tissue |
Type |
A1 Journal article |
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Year |
1984 |
Publication |
Journal de physique |
Abbreviated Journal |
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Volume |
45 |
Issue |
C:2 |
Pages |
561-564 |
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Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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ISSN |
0302-0738 |
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no |
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Call Number |
UA @ admin @ c:irua:116708 |
Serial |
7823 |
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Author |
Gielis, J. |
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Title |
Double helix of phyllotaxis : analysis of the geometric model of plant morphogenesis, by Boris Rozin |
Type |
Review |
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Year |
2021 |
Publication |
Quarterly Review Of Biology |
Abbreviated Journal |
Q Rev Biol |
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Volume |
96 |
Issue |
2 |
Pages |
139-140 |
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Keywords |
Review; Sustainable Energy, Air and Water Technology (DuEL) |
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Publication Date |
2021-05-19 |
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ISSN |
0033-5770; 1539-7718 |
ISBN |
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Additional Links |
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Impact Factor |
4.25 |
Times cited |
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Open Access |
Not_Open_Access |
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Notes |
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Approved |
Most recent IF: 4.25 |
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Call Number |
UA @ admin @ c:irua:178829 |
Serial |
7824 |
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Author |
Geerts, R.; Vandermoere, F.; Halet, D.; Joos, P.; Van Den Steen, K.; Van Meenen, E.; Blust, R.; Van Winckel, T.; Vlaeminck, S. |
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Title |
Drinking waste? An exploration of public support for wastewater reuse in Flanders |
Type |
P3 Proceeding |
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Year |
2020 |
Publication |
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Abbreviated Journal |
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Keywords |
P3 Proceeding; Sociology; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL); Centre for Research on Environmental and Social Change |
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Approved |
Most recent IF: NA |
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Call Number |
UA @ admin @ c:irua:186706 |
Serial |
7825 |
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Author |
Rojas, C.M.; Otten, P.M.; Van Grieken, R.E.; Laane, R. |
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Title |
Dry aerosol deposition over the North Sea estimated from aircraft measurements |
Type |
H3 Book chapter |
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Year |
1991 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
419-425
T2 - Air pollution modeling and its applic |
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Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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Call Number |
UA @ admin @ c:irua:680 |
Serial |
7826 |
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Author |
Shaw, P. |
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Title |
Dual action of reactive species as signal and stress agents in plasma medicine : combined computational and experimental research |
Type |
Doctoral thesis |
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Year |
2021 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
191 p. |
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Keywords |
Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT); Center for Oncological Research (CORE) |
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Abstract |
Reactive oxygen and nitrogen species (RONS) generated by cold atmospheric plasma (CAP) can activate discrete signaling transduction pathways or disrupt redox cellular homeostasis, depending on their concentration. This makes that CAP possesses therapeutic potential towards wound healing, cancer, and other diseases. In order to effectively use CAP in the clinic, a clear understanding of the interaction of RONS with biomolecules (lipids, proteins and nucleic acids) from the atomic to the macro scale, and their biological significance, is needed. In this work, I have therefore studied the dual role of CAP-derived RONS, i.e., (i) in the signaling pathways involved in wound healing, and (ii) in their reaction with biomolecules to cause oxidation-mediated damage. I performed computer simulations to provide fundamental insight about the occurring processes that are difficult or even impossible to obtain experimentally. Furthermore, next to computational studies, I used both 2D and 3D tissue cultures. 3D model allows proliferation in a more physiologically relevant geometry that stimulates the production of extracellular matrix proteins. I investigated the treatment of human gingival fibroblasts with low doses of CAP-generated RONS. This treatment demonstrated that it can inhibit colony formation but does not induce cell death, induce the expression of metalloprotease proteins, induce extracellular matrix degradation, and promote cell migration, which could result in enhanced wound healing. In contrast, at high concentrations, RONS can disrupt the cell membrane integrity and induce cancer cell death through oxidative stress-mediated pathways. I discovered how oxidation of the cell membrane (lipid-peroxidation) can facilitate the access of a drug (Melittin) into cancer cells, and in this way, reduce the required therapeutic dose of Melittin in melanoma and breast cancer cells (demonstrated using in vitro, in ovo and in silico approaches). Furthermore, I studied how excessive lipid-oxidation in chemoresistant pancreatic cancer cells promotes ferroptotic cell death. This was due to the stimulation of the iron-dependent Fenton reaction by targeting a redox specific signaling network. However, upon oxidative stress, cells protect themselves via a sophisticated intracellular antioxidant system that involves the regulation of glutathione/glutathione peroxidase 4 (lipid repair enzyme). Cancer cells exhibited increased levels of intracellular RONS due to their hyper metabolism, leading to high expression of anti-oxidant systems. I therefore focus on the effect of reactive species on the intracellular anti-oxidant system and corresponding DNA damages in both temozolomide-sensitive as well as temozolomide-resistant glioblastoma spheroids, in a 3-dimensional tumor model with a more complex tumor microenvironment than cell monolayers. |
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Approved |
Most recent IF: NA |
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Call Number |
UA @ admin @ c:irua:183751 |
Serial |
7828 |
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| Permanent link to this record |
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Author |
Reniers, G.L.L.; Sörensen, K.; Vrancken, K. |
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Title |
Editorial introduction |
Type |
H1 Book chapter |
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Year |
2013 |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
1-6
T2 - Management principles of sustainable indu |
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Keywords |
H1 Book chapter; Engineering Management (ENM); Sustainable Energy, Air and Water Technology (DuEL) |
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ISBN |
9783527649488 |
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UA library record |
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Approved |
no |
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Call Number |
UA @ admin @ c:irua:107601 |
Serial |
7833 |
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Author |
Keppens, E.; Roekens, E.; Van Grieken, R. |
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Title |
Effect of pollution on sandy limestones of a historical cathedral in Belgium |
Type |
P3 Proceeding |
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Year |
1985 |
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Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Notes |
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Approved |
no |
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Call Number |
UA @ admin @ c:irua:117499 |
Serial |
7838 |
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| Permanent link to this record |
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Author |
Leysen, L.; Roekens, E.; Van Grieken, R. |
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Title |
Effecten van luchtverontreiniging op historische gebouwen |
Type |
P3 Proceeding |
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Year |
1987 |
Publication |
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Abbreviated Journal |
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Issue |
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Pages |
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Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA library record |
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Open Access |
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Notes |
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Approved |
no |
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Call Number |
UA @ admin @ c:irua:117518 |
Serial |
7839 |
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| Permanent link to this record |
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Author |
Bernardi, A.; Becherini, F.; Kontozova, V.; Godoi, R.H.M.; Van Grieken, R.; Deutsch, F. |
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Title |
Effects of air pollution and microclimate on stained glass windows: prliminary results in the Sainte Chapelle (Paris) |
Type |
H3 Book chapter |
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Year |
2004 |
Publication |
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Issue |
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Pages |
133-140
T2 - Air pollution and cultural heritage / |
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Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA library record |
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Open Access |
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Notes |
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Approved |
no |
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Call Number |
UA @ admin @ c:irua:48940 |
Serial |
7843 |
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| Permanent link to this record |
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Author |
Van Grieken, R.; Vleugels, G.; Sweevers, E.; Dewolfs, R. |
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Title |
Effects of air pollution on historic buildings and monuments (1986-1990): scientific basis for conservation: analytical study of the weathering of building stones under field-exposure conditions |
Type |
A3 Journal article |
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Year |
1994 |
Publication |
European cultural heritage newsletter on research |
Abbreviated Journal |
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Volume |
8 |
Issue |
2 |
Pages |
2-7 |
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Keywords |
A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Open Access |
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Notes |
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Approved |
no |
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Call Number |
UA @ admin @ c:irua:55573 |
Serial |
7844 |
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| Permanent link to this record |
