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Author |
Pradhan, S.; Hu, J.; Ren, P.; Qin, Y.; Jain, N.; Monti, S.; Barcaro, G.; Jaworski, A.; Dai, X.; Rabeah, J.; Silvestre-Albero, J.; Celorrio, V.; Rokicinska, A.; Kustrowski, P.; Van Aert, S.; Bals, S.; Das, S. |
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Title |
An atomically dispersed photocatalyst for undirected para-selective C―H bond functionalizations |
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A1 Journal article |
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Year  |
2025 |
Publication |
Angewandte Chemie – international edition |
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64 |
Issue |
33 |
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1-11 |
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Keywords |
A1 Journal article; Electron microscopy for materials research (EMAT); Organic synthesis (ORSY) |
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Abstract |
Regioselective C & horbar;H bond functionalization is pivotal in modern scientific exploration, offering solutions for achieving novel synthetic methodologies and pharmaceutical development. In this aspect, achieving exceptional regioselective functionalization, like para-selective products in electron-poor aromatics, diverges from traditional methods. Leveraging the advantages of atomically dispersed photocatalysts, we designed a robust photocatalyst for an unconventional regioselective aromatic C & horbar;H bond functionalization. This innovation enabled para-selective trifluoromethylations of electron-deficient metadirecting aromatics (& horbar;NO2, & horbar;CF3, & horbar;CN, etc.), which is entirely orthogonal to the traditional approaches. Mechanistic experiments and DFT analysis confirmed the interaction between Cu-atom and the aromatic substrate, alongside the photocatalyst's molecular arrangement, driving selective exposure of the para-selective functionalization. This strategic approach elucidated pathways for precise molecular transformations, advancing the frontier of regioselective C & horbar;H bond functionalization by using atomically dispersed photocatalysts in organic synthesis. |
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WOS:001519948400001 |
Publication Date |
2025-06-11 |
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UA library record; WoS full record |
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Open Access |
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Call Number |
UA @ admin @ c:irua:216144 |
Serial |
9409 |
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