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Author |
Shani, J.; Barak, S.; Levi, D.; Ram, M.; Schachner, E.R.; Schlesinger, T.; Robberecht, H.; Van Grieken, R.; Avrach, W.W. |
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Title |
Skin penetration of minerals in psoriatics and guinea-pigs bathing in hypertonic salt solutions |
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A3 Journal article |
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Year  |
1985 |
Publication |
Pharmacological research communications |
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Volume |
17 |
Issue |
6 |
Pages |
501-512 |
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Keywords |
A3 Journal article; Pharmacology. Therapy; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Abstract |
Penetration of electrolytes through the human skin was measured in healthy volunteers and in psoriatic patients after bathing in the Dead-Sea or in simulated bath-salt solutions. Significant increases in the levels of serum Br, Rb, Ca and Zn were noticed only in the psoriatic patients after daily bathing in the Dead-Sea for a 4-week regimen. Guinea-pigs bathed in simulated Dead-Sea bath-salt solutions containing radionuclides of Ca, Mg, K and Br. Traces of each radionuclide were detected in the blood and in some internal organs after 60 minutes of bathing. The radionuclides showed a physiological pattern in their organ distribution. Even though the whole investigation was carried out in hypertonic solutions, there is a definite penetration of salts through healthy (human and guinea-pigs) and damaged (psoriatic) epidermis. This finding suggests that improvement of the psoriatic condition after bathing in the Dead-Sea, may be partly attributed (in addition to ultraviolet irradiation) to the minerals' effect on the psoriatic skin. |
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Publication Date |
2006-07-20 |
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ISSN |
0031-6989 |
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Additional Links |
UA library record |
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Open Access |
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Call Number |
UA @ admin @ c:irua:116755 |
Serial |
8547 |
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