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Author Pilehvar, S.; Dierckx, T.; Blust, R.; Breugelmans, T.; De Wael, K. url  doi
openurl 
  Title An electrochemical impedimetric aptasensing platform for sensitive and selective detection of small molecules such as chloramphenicol Type A1 Journal article
  Year (down) 2014 Publication Sensors Abbreviated Journal Sensors-Basel  
  Volume 14 Issue 7 Pages 12059-12069  
  Keywords A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Applied Electrochemistry & Catalysis (ELCAT)  
  Abstract We report on the aptadetection of chloramphenicol (CAP) using electrochemical impedance spectroscopy. The detection principle is based on the changes of the interfacial properties of the electrode after the interaction of the ssDNA aptamers with the target molecules. The electrode surface is partially blocked due to the formation of the aptamer-CAP complex, resulting in an increase of the interfacial electron-transfer resistance of the redox probe detected by electrochemical impedance spectroscopy or cyclic voltammetry. We observed that the ratio of polarization resistance had a linear relationship with the concentrations of CAP in the range of 1.76127 nM, and a detection limit of 1.76 nM was obtained. The covalent binding of CAP-aptamer on the electrode surface combined with the unique properties of aptamers and impedimetric transduction leads to the development of a stable and sensitive electrochemical aptasensor for CAP.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Wos 000340035700041 Publication Date 2014-07-07  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1424-8220 ISBN Additional Links UA library record; WoS full record; WoS citing articles  
  Impact Factor 2.677 Times cited 34 Open Access  
  Notes ; We are thankful to UA-DOCPRO and UA-BOFACA for financial support. ; Approved Most recent IF: 2.677; 2014 IF: 2.245  
  Call Number UA @ admin @ c:irua:117845 Serial 5592  
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