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Author Playford, K.; Colin, J.L.; Pacyna, J.M.; Pirrone, N.; Schulz, M.; Van Grieken, R.; Wrembel, Z.
Title State-of-the-art and research needs for trace metals Type H3 Book chapter
Year 1998 Publication Abbreviated Journal
Volume Issue Pages 7-11 T2 - Sea-air exchange: processes and modellin
Keywords H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:20972 Serial 8580
Permanent link to this record
 

 
Author Margui, E.; Van Grieken, R.
Title State-of-the-art X-ray fluorescence instrumentation for chemical analysis Type A3 Journal article
Year 2013 Publication Petro Industry News Abbreviated Journal
Volume Issue June/July Pages 16-18
Keywords A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract Nowadays, X-ray fluorescence spectrometry (XRF) is a well-established analytical technique for qualitative and quantitative elemental analysis (sometimes from Be to U) of a wide variety of samples. In particular, the truly multi-element character, acceptable speed and economy, ease of automation and the possibility to directly analyse solid samples are the most important features among the many that have made it a very mature analytical tool for routine quality controls in many industries, as well as for analytical support for the research laboratory.e recent technological advances, including the design of low-power micro-focus tubes and the novel X-ray optics and detectors have made it possible to extend XRF to the determination of low-Z elements and to obtain 2D or 3D information on a micrometre-scale. Furthermore, the recent development and commercialisation of benchtop and portable instrumentation, that offer extreme simplicity of operation in a low-cost design, have promoted even more the approach of XRF for many analytical problems.is article highlights this state-of-the art technique with regards to currently available XRF instrumentation on the market as well as recent applications in environmental and industrial fields.
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Corporate Author Thesis
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Series Editor Series Title Abbreviated Series Title
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ISSN 1472-0590 ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:109342 Serial 8581
Permanent link to this record
 

 
Author Van Grieken, R.
Title Stof : begrippen, bronnen en analysmethoden Type P3 Proceeding
Year 1985 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:117501 Serial 8582
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Author Injuk, J.; de Bock, L.; Van Grieken, R.
Title Structural heterogeneity within airborne particles Type H3 Book chapter
Year 1998 Publication Abbreviated Journal
Volume Issue Pages 173-202 T2 - Atmospheric particles / Harrison, R.M
Keywords H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:20969 Serial 8586
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Author Tavkhelidze, I.; Gielis, J.
Title Structure of the dm knives and process of cutting of GML(man) or GRT(man) bodies Type A3 Journal article
Year 2019 Publication Sn – 1512-0066 Abbreviated Journal
Volume 33 Issue Pages
Keywords A3 Journal article; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:164897 Serial 8588
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Author Grunert, O.; Robles Aguilar, A.A.; Hernandez-Sanabria, E.; Vandekerckhove, T.; Reheul, D.; Van Labeke, M.-C.; Vlaeminck, S.; Boon, N.; Jablonowski, N.D.
Title Struvite and organic fertilizer impacting the rhizosphere microbial community, nutrient turnover and plant growth performance Type P3 Proceeding
Year 2016 Publication Abbreviated Journal
Volume Issue Pages 12 p. T2 - WEF/IWA Nutrient Removal and Recovery C
Keywords P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:151135 Serial 8589
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Author Muys, M.; Derese, S.; Verliefde, A.; Vlaeminck, S.E.
Title Struvite solubilisation rates enable direct addition To single cell protein bioreactors Type P3 Proceeding
Year 2016 Publication Abbreviated Journal
Volume Issue Pages 10 p. T2 - WEF/IWA Nutrient Removal and Recovery C
Keywords P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:151129 Serial 8590
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Author Samek, L.; Worobiec, A.; Spolnik, Z.; Van Grieken, R.
Title Studia sezonowych zmian wewnetrznego składu powietrza atmosferycznego w kościołach zabytkowych w kontekście doboru i modyfikacji metod konserwacji obiektów zabytkowych Type H3 Book chapter
Year 2005 Publication Abbreviated Journal
Volume Issue Pages 59-64 T2 - Technika jadrowa w przemyśle, medycynie
Keywords H3 Book chapter; Laboratory Experimental Medicine and Pediatrics (LEMP); AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:53886 Serial 8591
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Author Cholewa, M.; Legge, G.J.F.; Eeckhaoudt, S.; Van Grieken, R.
Title A study of aluminium-exposed fish using a scanning proton microprobe Type P3 Proceeding
Year 1994 Publication Proceedings of the Australian Conference on Nuclear Techniques of Analysis Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:9517 Serial 8594
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Author Keulemans, M.
Title Study of electron transfer processes in plasmonic photocatalysis Type Doctoral thesis
Year 2017 Publication Abbreviated Journal
Volume Issue Pages 170 p.
Keywords Doctoral thesis; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:147504 Serial 8596
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Author Zezza, F.; Torfs, K.; Van Grieken, R.; García Pascua, N.; Macri, F.
Title Study of environmental effects on deterioration of monuments: case study the cathedral of Bari, Italy Type P3 Proceeding
Year 1996 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:14665 Serial 8597
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Author Bernard, P.; Van Grieken, R.; Eisma, D.
Title Study of individual estuarine suspension particles by automated electron-probe X-ray microanalysis Type P3 Proceeding
Year 1985 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:117498 Serial 8598
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Author Van Grieken, R.; Injuk, J.; de Bock, L.; van Malderen, H.
Title Study of individual particle types and heavy metal deposition for North Sea aerosols using micro and trace analysis techniques Type H3 Book chapter
Year 2000 Publication Abbreviated Journal
Volume Issue Pages 105-110 T2 - Exchange and transport of air polluta
Keywords H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:31676 Serial 8599
Permanent link to this record
 

 
Author Injuk, J.; de Bock, L.; van Malderen, H.; Van Grieken, R.
Title Study of individual particle types and heavy metal deposition for North Sea aerosols using micro- and trace analysis techniques Type P3 Proceeding
Year 1996 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:14682 Serial 8600
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Author Jones, K.W.; Feng, H.; Lindquist, W.B.; Adler, P.M.; Thover, J.F.; Vekemans, B.; Vincze, L.; Szalóki, I.; Van Grieken, R.; Adams, F.; Riekel, C.
Title Study of microgeometry of porous materials using synchrotron computed microtomography Type H3 Book chapter
Year 2003 Publication Abbreviated Journal
Volume Issue Pages 39-49 T2 - Applications of X-ray computed tomograp
Keywords H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:41596 Serial 8602
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Author Asapu, R.
Title A study of plasmonic systems using Layer-by-Layer synthesized core-shell nanoparticles Type Doctoral thesis
Year 2018 Publication Abbreviated Journal
Volume Issue Pages 142 p.
Keywords Doctoral thesis; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
Abstract
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Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:153373 Serial 8603
Permanent link to this record
 

 
Author Rojas, C.M.; Van Grieken, R.E.; Cantillano, M.E.
Title Study of the Antarctic aerosol using X-ray fluorescence and single particle analysis Type A3 Journal article
Year 1992 Publication Scientific series of the Chilean Antarctic Institute (Ser. Cinet. INACH) Abbreviated Journal
Volume 42 Issue Pages 37-45
Keywords A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:2839 Serial 8604
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Author Injuk, J.; van Malderen, H.; Van Grieken, R.
Title Study of the heavy metal concentration, deposition and sources of the North Sea aerosols using X-ray emission techniques Type H3 Book chapter
Year 1993 Publication Abbreviated Journal
Volume Issue Pages 793-795 T2 - Photo-oxidants: precursors and produc
Keywords H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date (up)
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:6266 Serial 8605
Permanent link to this record
 

 
Author Ghasemitarei, M.
Title Study of the interaction of plasma radicals with malignant tumor cells by means of Molecular Dynamics simulation Type Doctoral thesis
Year 2019 Publication Abbreviated Journal
Volume Issue Pages 117 p.
Keywords Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT)
Abstract abstract not available
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Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:164763 Serial 8606
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Author Leyva Pernia, D.; Cabal Rodríguez, A.E.; Schalm, O.; van Espen, P.; Piñera Hernández, I.; Abreu Alfonso, Y.
Title Study of the main physical processes contributing to image formation in emission radiography using mathematical modeling Type P3 Proceeding
Year 2013 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; Engineering sciences. Technology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Antwerp Cultural Heritage Sciences (ARCHES)
Abstract
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Series Editor Series Title Abbreviated Series Title
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ISSN ISBN 978-959-7136-98-9 Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:135412 Serial 8607
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Author Treiger, B.; Bondarenko, I.; van Malderen, H.; Van Grieken, R.
Title Studying the composition of atmospheric aerosols through the joint application of hierarchical, non-hierarchical and fuzzy clustering to EPXMA data sets Type P3 Proceeding
Year 1996 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Corporate Author Thesis
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Series Editor Series Title Abbreviated Series Title
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ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:14661 Serial 8611
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Author Joos, P.E.; Godoi, A.F.L.; de Jong, R.; de Zeeuw, J.; Van Grieken, R.
Title Sub-minute determination of BTEX in environmental samples using low pressure GC-ITMS Type P3 Proceeding
Year 2002 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Corporate Author Thesis
Publisher Place of Publication Editor
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Series Editor Series Title Abbreviated Series Title
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Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:38153 Serial 8612
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Author Maenhaut, W.; Selen, A.; van Espen, P.; Van Grieken, R.; Winchester, J.W.
Title Sulfur and heavy metals over the Atlantic Ocean : comparison with other marine data Type P3 Proceeding
Year 1980 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Chemometrics (Mitac 3)
Abstract
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Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:117480 Serial 8618
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Author Vlaeminck, S.E.; Kobayashi, K.; Jandra, J.; Van Nevel, S.; Vandekerckhove, T.G.L.
Title Sulphidotrophic denitrification treating regeneration water from ion exchange at high performance and low opex Type P3 Proceeding
Year 2017 Publication Abbreviated Journal
Volume Issue Pages 3 p. T2 - IWA 2017 Conference on Sustainable Waste
Keywords P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
Abstract
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Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:151108 Serial 8620
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Author Tummers, A.; Wallert, A.; De Keyser, N.
Title Supplementing the eye : the technical analysis of Frans Hals's paintings – ii Type A1 Journal article
Year 2019 Publication The Burlington magazine Abbreviated Journal
Volume 161 Issue 1401 Pages 996-1003
Keywords A1 Journal article; Art; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract The painting 'Two fisherboys' has long caused confusion among experts. A close comparison of the painting with a forgery by Han van Meegeren and Frans Hals's `Fisherboy' solves the conundrum and provides valuable insights into the merits and drawbacks of modern analytical techniques.
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Language Wos 000500540400006 Publication Date (up)
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ISSN 0007-6287; 2044-9925 ISBN Additional Links UA library record; WoS full record; WoS citing articles
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:165106 Serial 8624
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Author Vincze, L.; Vekemans, B.; Adams, F.
Title Synchrotron computed X-ray fluorescence microtomography in environmental and earth sciences Type P3 Proceeding
Year 2003 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Series Editor Series Title Abbreviated Series Title
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Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:43187 Serial 8632
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Author Vincze, L.; Vekemans, B.; Adams, F.
Title Synchrotron computed X-ray fluorescence tomography in environmental and earth sciences: radiation Type P3 Proceeding
Year 2004 Publication Abbreviated Journal
Volume Issue Pages
Keywords P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Series Editor Series Title Abbreviated Series Title
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Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:46497 Serial 8633
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Author Adams, F.; Vincze, L.; Vekemans, B.
Title Synchrotron radiation for microscopic X-ray fluorescence analysis Type H3 Book chapter
Year 2004 Publication Abbreviated Journal
Volume Issue Pages 343-353 T2 - X-ray spectrometry: recent technologi
Keywords H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
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Notes Approved no
Call Number UA @ admin @ c:irua:46499 Serial 8634
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Author Smits, J.; Van Grieken, R.
Title Synthesis of a chelating cellulose filter with 2,2-diaminodiethylamine functional groups Type A3 Journal article
Year 1978 Publication Zeitschrift für angewandte Makromolekare Chemie Abbreviated Journal
Volume 72 Issue Pages 105-113
Keywords A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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Notes Approved no
Call Number UA @ admin @ c:irua:116644 Serial 8637
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Author Van Loenhout, J.
Title Targeting pancreatic ductal adenocarcinoma and glioblastoma with oxidative stress-mediated treatment strategies : focus on tumor cell death and modulation of the tumor microenvironment Type Doctoral thesis
Year 2021 Publication Abbreviated Journal
Volume Issue Pages 167 p.
Keywords Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT); Center for Oncological Research (CORE)
Abstract Pancreatic ductal adenocarcinoma (PDAC) and glioblastoma multiforme (GBM) are two of the most malignant solid tumor types with poor survival rates, which underscore the urgency of novel and efficacious treatment strategies. Within the last decade, immunotherapy has been established as a breakthrough in cancer therapy. This mainly has been driven by the clinical data and approval associated with several immune checkpoint inhibitors (e.g. anti-CTLA-4 and anti-PD-1/L1). Despite the clinical benefit in specific tumor types, these inhibitors have not yet fulfilled their promise in low immunogenic tumors such as PDAC and GBM. Oxidative stress in cancer cells due to elevated reactive oxygen species (ROS) and an inability to balance intracellular redox state has recently been highlighted as promising target for anticancer treatment strategies with possible immunogenic effects. In this PhD dissertation, I investigated novel oxidative stress-mediated treatment approaches to target PDAC and GBM and to enhance immunogenicity by inducing immunogenic cell death (ICD). In the first part of this thesis (chapter 2), I reviewed the mechanistic responses of cancer cells towards different oxidative stress-inducing treatment strategies and their immunomodulating effects. The resulting literature demonstrated that different exogenous and endogenous ROS-inducing therapies show direct and indirect immunomodulating effects, which can be either immunostimulatory or immunosuppressive. One of the indirect immunostimulatory effects of the ROS-mediating therapies is the capacity of inducing immunogenic cell death (ICD) in tumor cells, which can increase the immunogenicity and consequently can trigger an antitumoral immune response. In chapter 3, I investigated a novel exogenous ROS-inducing treatment method, namely cold atmospheric plasma, to determine the therapeutic and ICD-inducing effects in PDAC, in vitro. I revealed that plasma-treated PBS (pPBS) has the potential to induce ICD in pancreatic cancer cells (PCCs) and to reduce the immunosuppressive tumor microenvironment (TME) by attacking the tumor supportive pancreatic stellate cells (PSCs). Although the cell death induced in PSCs was non-immunogenic as seen by the lack of danger-associated molecular patterns (DAMPs) emission and DC activation, I showed that pPBS could disrupt the physical barrier and lower the immunosuppressive secretion profile (lower TGF-β) of PSCs. In contrast, DAMPs were released by PCCs after treatment with pPBS which resulted in activation and maturation of DCs and a more immunostimulatory secretion profile (higher TNF-α, IFN-γ). Hence, indirect plasma treatment via pPBS has the potential to enhance immunogenicity in PDAC by triggering ICD and by attacking the immunosuppressive PSCs. Tumor cells can evolve adaptation mechanisms to protect themselves against intrinsic oxidative stress by upregulation of pro-survival molecules and their antioxidant defense system to maintain the redox balance. As such, tumor cells can become resistant towards exogenous ROS-inducing therapies, like plasma. Dual targeting of the redox balance of tumor cells by increasing exogenous levels of ROS and inhibiting the antioxidant defense system can maximally exploit ROS-mediated cell death mechanisms as therapeutic anticancer strategy. In this regard, cold atmospheric plasma was combined with auranofin, a thioredoxin reductase inhibitor, in GBM (chapter 4). A synergistic effect was shown after this combination treatment in 2D and 3D, however, in 3D only high concentrations of auranofin synergized with plasma treatment. I confirmed a ROS-mediated response after combination treatment, which was able to induce distinct cell death mechanisms, specifically apoptosis and ferroptosis. Additionally, the auranofin and plasma combined treatment strategy induced cell death, which resulted in an increased release of DAMPs. Together with the observed DC maturation, these results indicates the potential increase in immunogenicity, though, the phagocytotic capacity of DCs was inhibited by auranofin. In chapter 5, I evaluated this promising oxidative stress combination therapy in GBM, in vivo. A decrease in tumor kinetics and an increased survival in GBM-bearing mice was observed when auranofin was sequentially combined with direct plasma treatment. No T cell infiltration was observed after auranofin monotherapy. However, further characterization of the TME after the combination therapy is necessary to provide more insight in the immunogenic effects in vivo. In conclusion, this PhD dissertation comprises novel and important therapeutic and immunogenic insights in cold atmospheric plasma and auranofin as promising oxidative stress-mediated treatment strategies for low immunogenic tumors, like PDAC and GBM. These preclinical results provide a solid basis for future research towards combinations with immunotherapeutic approaches.
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Notes Approved Most recent IF: NA
Call Number UA @ admin @ c:irua:181309 Serial 8643
Permanent link to this record