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Ghasemitarei, M. |
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Title |
Study of the interaction of plasma radicals with malignant tumor cells by means of Molecular Dynamics simulation |
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Doctoral thesis |
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2019 |
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117 p. |
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Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT) |
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abstract not available |
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UA @ admin @ c:irua:164763 |
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8606 |
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Leyva Pernia, D.; Cabal Rodríguez, A.E.; Schalm, O.; van Espen, P.; Piñera Hernández, I.; Abreu Alfonso, Y. |
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Study of the main physical processes contributing to image formation in emission radiography using mathematical modeling |
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P3 Proceeding |
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2013 |
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P3 Proceeding; Engineering sciences. Technology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Antwerp Cultural Heritage Sciences (ARCHES) |
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978-959-7136-98-9 |
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UA @ admin @ c:irua:135412 |
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8607 |
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Treiger, B.; Bondarenko, I.; van Malderen, H.; Van Grieken, R. |
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Studying the composition of atmospheric aerosols through the joint application of hierarchical, non-hierarchical and fuzzy clustering to EPXMA data sets |
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P3 Proceeding |
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1996 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:14661 |
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8611 |
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Joos, P.E.; Godoi, A.F.L.; de Jong, R.; de Zeeuw, J.; Van Grieken, R. |
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Title |
Sub-minute determination of BTEX in environmental samples using low pressure GC-ITMS |
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P3 Proceeding |
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2002 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:38153 |
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8612 |
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Author |
Maenhaut, W.; Selen, A.; van Espen, P.; Van Grieken, R.; Winchester, J.W. |
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Title |
Sulfur and heavy metals over the Atlantic Ocean : comparison with other marine data |
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P3 Proceeding |
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1980 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Chemometrics (Mitac 3) |
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UA @ admin @ c:irua:117480 |
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8618 |
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Vlaeminck, S.E.; Kobayashi, K.; Jandra, J.; Van Nevel, S.; Vandekerckhove, T.G.L. |
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Sulphidotrophic denitrification treating regeneration water from ion exchange at high performance and low opex |
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P3 Proceeding |
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2017 |
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3 p.
T2 - IWA 2017 Conference on Sustainable Waste |
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P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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UA @ admin @ c:irua:151108 |
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8620 |
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Reniers, G.; Sörensen, K.; Vrancken, K. |
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Title |
Sustainable industrial chemistry from a nontechnological viewpoint |
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H1 Book chapter |
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2013 |
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33-41
T2 - Management principles of sustainable in |
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H1 Book chapter; Economics; Engineering Management (ENM); Sustainable Energy, Air and Water Technology (DuEL) |
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2013-03-14 |
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9783527330997; 9783527649488 |
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Call Number |
UA @ admin @ c:irua:106566 |
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8629 |
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Author |
Vincze, L.; Vekemans, B.; Adams, F. |
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Title |
Synchrotron computed X-ray fluorescence microtomography in environmental and earth sciences |
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P3 Proceeding |
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2003 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:43187 |
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8632 |
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Vincze, L.; Vekemans, B.; Adams, F. |
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Synchrotron computed X-ray fluorescence tomography in environmental and earth sciences: radiation |
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P3 Proceeding |
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2004 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:46497 |
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8633 |
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Adams, F.; Vincze, L.; Vekemans, B. |
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Synchrotron radiation for microscopic X-ray fluorescence analysis |
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H3 Book chapter |
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2004 |
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343-353
T2 - X-ray spectrometry: recent technologi |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:46499 |
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8634 |
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Smits, J.; Van Grieken, R. |
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Synthesis of a chelating cellulose filter with 2,2-diaminodiethylamine functional groups |
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A3 Journal article |
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1978 |
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Zeitschrift für angewandte Makromolekare Chemie |
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72 |
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105-113 |
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A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:116644 |
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8637 |
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Van Loenhout, J. |
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Targeting pancreatic ductal adenocarcinoma and glioblastoma with oxidative stress-mediated treatment strategies : focus on tumor cell death and modulation of the tumor microenvironment |
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Doctoral thesis |
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2021 |
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167 p. |
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Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT); Center for Oncological Research (CORE) |
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Pancreatic ductal adenocarcinoma (PDAC) and glioblastoma multiforme (GBM) are two of the most malignant solid tumor types with poor survival rates, which underscore the urgency of novel and efficacious treatment strategies. Within the last decade, immunotherapy has been established as a breakthrough in cancer therapy. This mainly has been driven by the clinical data and approval associated with several immune checkpoint inhibitors (e.g. anti-CTLA-4 and anti-PD-1/L1). Despite the clinical benefit in specific tumor types, these inhibitors have not yet fulfilled their promise in low immunogenic tumors such as PDAC and GBM. Oxidative stress in cancer cells due to elevated reactive oxygen species (ROS) and an inability to balance intracellular redox state has recently been highlighted as promising target for anticancer treatment strategies with possible immunogenic effects. In this PhD dissertation, I investigated novel oxidative stress-mediated treatment approaches to target PDAC and GBM and to enhance immunogenicity by inducing immunogenic cell death (ICD). In the first part of this thesis (chapter 2), I reviewed the mechanistic responses of cancer cells towards different oxidative stress-inducing treatment strategies and their immunomodulating effects. The resulting literature demonstrated that different exogenous and endogenous ROS-inducing therapies show direct and indirect immunomodulating effects, which can be either immunostimulatory or immunosuppressive. One of the indirect immunostimulatory effects of the ROS-mediating therapies is the capacity of inducing immunogenic cell death (ICD) in tumor cells, which can increase the immunogenicity and consequently can trigger an antitumoral immune response. In chapter 3, I investigated a novel exogenous ROS-inducing treatment method, namely cold atmospheric plasma, to determine the therapeutic and ICD-inducing effects in PDAC, in vitro. I revealed that plasma-treated PBS (pPBS) has the potential to induce ICD in pancreatic cancer cells (PCCs) and to reduce the immunosuppressive tumor microenvironment (TME) by attacking the tumor supportive pancreatic stellate cells (PSCs). Although the cell death induced in PSCs was non-immunogenic as seen by the lack of danger-associated molecular patterns (DAMPs) emission and DC activation, I showed that pPBS could disrupt the physical barrier and lower the immunosuppressive secretion profile (lower TGF-β) of PSCs. In contrast, DAMPs were released by PCCs after treatment with pPBS which resulted in activation and maturation of DCs and a more immunostimulatory secretion profile (higher TNF-α, IFN-γ). Hence, indirect plasma treatment via pPBS has the potential to enhance immunogenicity in PDAC by triggering ICD and by attacking the immunosuppressive PSCs. Tumor cells can evolve adaptation mechanisms to protect themselves against intrinsic oxidative stress by upregulation of pro-survival molecules and their antioxidant defense system to maintain the redox balance. As such, tumor cells can become resistant towards exogenous ROS-inducing therapies, like plasma. Dual targeting of the redox balance of tumor cells by increasing exogenous levels of ROS and inhibiting the antioxidant defense system can maximally exploit ROS-mediated cell death mechanisms as therapeutic anticancer strategy. In this regard, cold atmospheric plasma was combined with auranofin, a thioredoxin reductase inhibitor, in GBM (chapter 4). A synergistic effect was shown after this combination treatment in 2D and 3D, however, in 3D only high concentrations of auranofin synergized with plasma treatment. I confirmed a ROS-mediated response after combination treatment, which was able to induce distinct cell death mechanisms, specifically apoptosis and ferroptosis. Additionally, the auranofin and plasma combined treatment strategy induced cell death, which resulted in an increased release of DAMPs. Together with the observed DC maturation, these results indicates the potential increase in immunogenicity, though, the phagocytotic capacity of DCs was inhibited by auranofin. In chapter 5, I evaluated this promising oxidative stress combination therapy in GBM, in vivo. A decrease in tumor kinetics and an increased survival in GBM-bearing mice was observed when auranofin was sequentially combined with direct plasma treatment. No T cell infiltration was observed after auranofin monotherapy. However, further characterization of the TME after the combination therapy is necessary to provide more insight in the immunogenic effects in vivo. In conclusion, this PhD dissertation comprises novel and important therapeutic and immunogenic insights in cold atmospheric plasma and auranofin as promising oxidative stress-mediated treatment strategies for low immunogenic tumors, like PDAC and GBM. These preclinical results provide a solid basis for future research towards combinations with immunotherapeutic approaches. |
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Most recent IF: NA |
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UA @ admin @ c:irua:181309 |
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8643 |
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Gielis, J. |
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Temperate bamboos in ornamental horticulture: differentiators and spillover effects into the 21st century |
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H3 Book chapter |
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2012 |
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603-623
T2 - Proceedings of the 9th World Bamboo C |
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H3 Book chapter; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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UA @ admin @ c:irua:97755 |
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8644 |
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Xiao, Y. |
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Theoretical study of the optoelectronic properties of new type 2DEG materials : multilayer graphene and monolayer MoS2 |
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Doctoral thesis |
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2017 |
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Abbreviated Journal |
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144 p. |
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Doctoral thesis; Condensed Matter Theory (CMT) |
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UA @ admin @ c:irua:144948 |
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8661 |
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Taghizadeh Sisakht, E. |
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Tight-binding investigation of the electronic properties of phosphorene and phosphorene nanoribbons |
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Doctoral thesis |
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2019 |
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Abbreviated Journal |
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150 p. |
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Doctoral thesis; Condensed Matter Theory (CMT) |
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abstract not available |
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Open Access |
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Notes |
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Approved |
no |
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Call Number |
UA @ admin @ c:irua:166195 |
Serial |
8670 |
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| Permanent link to this record |
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Author |
Nakhaee, M. |
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| |
Title |
Tight-binding model for two-dimensional materials |
Type |
Doctoral thesis |
| |
Year |
2020 |
Publication |
|
Abbreviated Journal |
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Volume |
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Issue |
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Pages |
139 p. |
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Keywords |
Doctoral thesis; Condensed Matter Theory (CMT) |
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Abstract |
abstract not available |
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Approved |
Most recent IF: NA |
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Call Number |
UA @ admin @ c:irua:166134 |
Serial |
8671 |
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| Permanent link to this record |
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| |
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Author |
De Clippeleir, H.; Vlaeminck, S.E.; Courtens, E.N.P.; Jimenez, J.; Wadhawan, T.; Zhang, Q. |
|
| |
Title |
Toward energy autarky : carbon redirection coupled with shortcut nitrogen processes |
Type |
H3 Book chapter |
| |
Year |
2015 |
Publication |
|
Abbreviated Journal |
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| |
Volume |
|
Issue |
|
Pages |
129-150
T2 - Shortcut nitrogen removal : nitrite s |
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Keywords |
H3 Book chapter; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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ISSN |
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ISBN |
978-1-57278-313-3 |
Additional Links |
UA library record |
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Notes |
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Approved |
no |
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Call Number |
UA @ admin @ c:irua:130470 |
Serial |
8676 |
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| Permanent link to this record |
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| |
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Author |
Gielis, J.; Ding, Y.; Shi, P. |
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| |
Title |
Towards a geometrical theory of morphology and morphogenesis |
Type |
P3 Proceeding |
| |
Year |
2016 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
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Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Additional Links |
UA library record |
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|
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|
Open Access |
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|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:144548 |
Serial |
8677 |
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| Permanent link to this record |
| |
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| |
|
Author |
Mozo, I.; Lacoste, L.; aussenac, J.; De Cocker, P.; Vlaeminck, S.E.; Sperandio, M.; Caligaris, M.; Graveleau, L.; Barillon, B.; Martin Ruel, S. |
|
| |
Title |
Towards application of mainstream deammonification on municipal wastewater in warm and cold areas |
Type |
P3 Proceeding |
| |
Year |
2016 |
Publication |
|
Abbreviated Journal |
|
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| |
Volume |
|
Issue |
|
Pages |
4 p.
T2 - World Cities Summit, Singapore Internati |
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| |
Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Additional Links |
UA library record |
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Impact Factor |
|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:151124 |
Serial |
8678 |
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| Permanent link to this record |
| |
|
| |
|
Author |
Mozo, I.; Lacoste, L.; Aussenac, J.; De Cocker, P.; Vlaeminck, S.E.; Sperandio, M.; Caligaris, M.; Barillon, B.; Martin Ruel, S. |
|
| |
Title |
Towards application of mainstream deammonification on municipal wastewater in warm and cold areas |
Type |
P3 Proceeding |
| |
Year |
2016 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
4 p.
T2 - WEF/IWA Nutrient Removal and Recovery Co |
|
| |
Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Additional Links |
UA library record |
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Impact Factor |
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Open Access |
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|
| |
Notes |
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Approved |
no |
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| |
Call Number |
UA @ admin @ c:irua:151136 |
Serial |
8679 |
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| Permanent link to this record |
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| |
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Author |
Alloul, A.; Vlaeminck, S.E. |
|
| |
Title |
Towards upgrading of wastewater resources to microbial protein : volatile fatty acids impacting growth kinetics and yield of purple bacteria |
Type |
P3 Proceeding |
| |
Year |
2017 |
Publication |
|
Abbreviated Journal |
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| |
Volume |
|
Issue |
|
Pages |
2 p.
T2 - 5th IWA Benelux Young Water Professional |
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| |
Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Additional Links |
UA library record |
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| |
Impact Factor |
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|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:151115 |
Serial |
8683 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Joos, P.E.; Godoi, A.F.L.; de Jong, R.; de Zeeuw, J.; Van Grieken, R. |
|
| |
Title |
Trace analysis of benzene, toluene, ethylbenzene and xylene isomers in environmental samples by low-pressure gas chromatography-ion trap mass spectrometry |
Type |
A1 Journal article |
| |
Year |
2003 |
Publication |
Journal of chromatography: A: bibliography section |
Abbreviated Journal |
|
|
| |
Volume |
985 |
Issue |
|
Pages |
191-196 |
|
| |
Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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| |
Abstract |
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Wos |
000180580400024 |
Publication Date |
2003-02-04 |
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| |
Series Editor |
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| |
Series Volume |
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Edition |
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| |
ISSN |
|
ISBN |
|
Additional Links |
UA library record; WoS full record; WoS citing articles |
|
| |
Impact Factor |
|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:40612 |
Serial |
8685 |
|
| Permanent link to this record |
| |
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| |
|
Author |
Van Grieken, R.E.; LaBrecque, J.J. |
|
| |
Title |
Trace analysis of environmental samples by X-ray emission spectroscopy |
Type |
H3 Book chapter |
| |
Year |
1985 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
101-183
T2 - Trace analysis : vol. 4 / Lawrence, J |
|
| |
Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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| |
Abstract |
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Edition |
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ISSN |
|
ISBN |
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Additional Links |
UA library record |
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| |
Impact Factor |
|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:117495 |
Serial |
8686 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Artaxo, P.; Rabello, M.L.C.; Maenhaut, W.; Van Grieken, R. |
|
| |
Title |
Trace elements and individual particle analysis of atmospheric aerosols from the Antarctic peninsula |
Type |
A3 Journal article |
| |
Year |
1992 |
Publication |
Tellus |
Abbreviated Journal |
|
|
| |
Volume |
44b |
Issue |
|
Pages |
318-334 |
|
| |
Keywords |
A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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| |
Abstract |
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Edition |
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|
ISBN |
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Additional Links |
UA library record |
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| |
Impact Factor |
|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:2845 |
Serial |
8689 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Winchester, J.W.; Meinert, D.L.; Nelson, J.W.; Johansson, T.B.; Van Grieken, R.E.; Orsini, C.; Kaufmann, H.C.; Akselsson, R. |
|
| |
Title |
Trace metals in the St-Louis aerosol |
Type |
H3 Book chapter |
| |
Year |
1975 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
385-394
T2 - Nuclear techniques in environmental r |
|
| |
Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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| |
Abstract |
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Address |
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Edition |
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| |
ISSN |
|
ISBN |
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Additional Links |
UA library record |
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| |
Impact Factor |
|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:117459 |
Serial |
8694 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Vandekerckhove, T.; Courtens, E.N.P.; Prat, D.; Vilchez-Vargas, R.; Vital, M.; Pieper, D.H.; Meerbergen, K.; Lievens, B.; Boon, N.; Vlaeminck, S.E. |
|
| |
Title |
Transitioning from mesophilic to thermophilic nitrification: shaping a niche for archaeal ammonia oxidizers |
Type |
P3 Proceeding |
| |
Year |
2016 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
9 p.
T2 - WEF/IWA Nutrient Removal and Recovery Co |
|
| |
Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Abstract |
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Additional Links |
UA library record |
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| |
Impact Factor |
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Times cited |
|
Open Access |
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|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:151126 |
Serial |
8697 |
|
| Permanent link to this record |
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| |
|
Author |
Mishra, V.K.; Dons, E.; Panis, L.I.; Frijns, E.; van Poppel, M.; Berghmans, P.; Bleux, N.; Wuyts, K.; Samson, R. |
|
| |
Title |
Understanding ultrafine particles dynamics within a one km urban grid |
Type |
P3 Proceeding |
| |
Year |
2010 |
Publication |
|
Abbreviated Journal |
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| |
Volume |
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Issue |
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Pages |
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Keywords |
P3 Proceeding; Sustainable Energy, Air and Water Technology (DuEL) |
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Additional Links |
UA library record |
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| |
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|
Times cited |
|
Open Access |
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|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:88671 |
Serial |
8709 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
de Gendt, S.; Kenis, K.; Mertens, P.W.; Heyns, M.M.; Claes, M.; Van Grieken, R.E.; Bailleul, A.; Knotter, M.; de Bokx, P.K. |
|
| |
Title |
Use of grazing emission XRF spectrometry for silicon wafer surface contamination measurements |
Type |
P3 Proceeding |
| |
Year |
1996 |
Publication |
|
Abbreviated Journal |
|
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| |
Volume |
|
Issue |
|
Pages |
|
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| |
Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Abstract |
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Edition |
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|
ISBN |
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Additional Links |
UA library record |
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| |
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|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:14679 |
Serial |
8720 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Godoi, A.F.L.; Van Vaeck, L.; Van Grieken, R. |
|
| |
Title |
Use of solid-phase microextraction for the detection of acetic acid by ion-trap gas chromatography-mass spectrometry and application to indoor levels in museums |
Type |
A1 Journal article |
| |
Year |
2005 |
Publication |
Journal of chromatography: A: bibliography section |
Abbreviated Journal |
|
|
| |
Volume |
1067 |
Issue |
|
Pages |
331-336 |
|
| |
Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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| |
Abstract |
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| |
Address |
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Place of Publication |
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| |
Language |
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Wos |
000227925800032 |
Publication Date |
2005-01-26 |
|
| |
Series Editor |
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|
Abbreviated Series Title |
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| |
Series Volume |
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Series Issue |
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Edition |
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ISSN |
|
ISBN |
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Additional Links |
UA library record; WoS full record; WoS citing articles |
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| |
Impact Factor |
|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:51590 |
Serial |
8723 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Amiri-Aref, M. |
|
| |
Title |
Utilization of magnetic nanoparticles and carbon nanotubes to fabrication electrochemical sensors for determination of some important biological and pharmaceutical compounds |
Type |
Doctoral thesis |
| |
Year |
2015 |
Publication |
|
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
137 p. |
|
| |
Keywords |
Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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| |
Abstract |
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Address |
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Wos |
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Series Editor |
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| |
Series Volume |
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Series Issue |
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Edition |
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| |
ISSN |
|
ISBN |
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Additional Links |
UA library record |
|
| |
Impact Factor |
|
Times cited |
|
Open Access |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
UA @ admin @ c:irua:128299 |
Serial |
8727 |
|
| Permanent link to this record |
