“Study of microgeometry of porous materials using synchrotron computed microtomography”. Jones KW, Feng H, Lindquist WB, Adler PM, Thover JF, Vekemans B, Vincze L, Szalóki I, Van Grieken R, Adams F, Riekel C page 39 (2003).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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Asapu R (2018) A study of plasmonic systems using Layer-by-Layer synthesized core-shell nanoparticles. 142 p
Keywords: Doctoral thesis; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Study of the heavy metal concentration, deposition and sources of the North Sea aerosols using X-ray emission techniques”. Injuk J, van Malderen H, Van Grieken R page 793 (1993).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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Ghasemitarei M (2019) Study of the interaction of plasma radicals with malignant tumor cells by means of Molecular Dynamics simulation. 117 p
Abstract: abstract not available
Keywords: Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT)
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“Study of the main physical processes contributing to image formation in emission radiography using mathematical modeling”. Leyva Pernia D, Cabal Rodríguez AE, Schalm O, van Espen P, Piñera Hernández I, Abreu Alfonso Y, (2013)
Keywords: P3 Proceeding; Engineering sciences. Technology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Antwerp Cultural Heritage Sciences (ARCHES)
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“Studying the composition of atmospheric aerosols through the joint application of hierarchical, non-hierarchical and fuzzy clustering to EPXMA data sets”. Treiger B, Bondarenko I, van Malderen H, Van Grieken R, (1996)
Keywords: P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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“Sub-minute determination of BTEX in environmental samples using low pressure GC-ITMS”. Joos PE, Godoi AFL, de Jong R, de Zeeuw J, Van Grieken R, (2002)
Keywords: P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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“Sulfur and heavy metals over the Atlantic Ocean : comparison with other marine data”. Maenhaut W, Selen A, van Espen P, Van Grieken R, Winchester JW, (1980)
Keywords: P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Chemometrics (Mitac 3)
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“Sulphidotrophic denitrification treating regeneration water from ion exchange at high performance and low opex”. Vlaeminck SE, Kobayashi K, Jandra J, Van Nevel S, Vandekerckhove TGL, , 3 p.
T2 (2017)
Keywords: P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Sustainable industrial chemistry from a nontechnological viewpoint”. Reniers G, Sörensen K, Vrancken K page 33 (2013).
Keywords: H1 Book chapter; Economics; Engineering Management (ENM); Sustainable Energy, Air and Water Technology (DuEL)
DOI: 10.1002/9783527649488.CH4
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“Synchrotron computed X-ray fluorescence microtomography in environmental and earth sciences”. Vincze L, Vekemans B, Adams F, (2003)
Keywords: P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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“Synchrotron computed X-ray fluorescence tomography in environmental and earth sciences: radiation”. Vincze L, Vekemans B, Adams F, (2004)
Keywords: P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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“Synchrotron radiation for microscopic X-ray fluorescence analysis”. Adams F, Vincze L, Vekemans B page 343 (2004).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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Van Loenhout J (2021) Targeting pancreatic ductal adenocarcinoma and glioblastoma with oxidative stress-mediated treatment strategies : focus on tumor cell death and modulation of the tumor microenvironment. 167 p
Abstract: Pancreatic ductal adenocarcinoma (PDAC) and glioblastoma multiforme (GBM) are two of the most malignant solid tumor types with poor survival rates, which underscore the urgency of novel and efficacious treatment strategies. Within the last decade, immunotherapy has been established as a breakthrough in cancer therapy. This mainly has been driven by the clinical data and approval associated with several immune checkpoint inhibitors (e.g. anti-CTLA-4 and anti-PD-1/L1). Despite the clinical benefit in specific tumor types, these inhibitors have not yet fulfilled their promise in low immunogenic tumors such as PDAC and GBM. Oxidative stress in cancer cells due to elevated reactive oxygen species (ROS) and an inability to balance intracellular redox state has recently been highlighted as promising target for anticancer treatment strategies with possible immunogenic effects. In this PhD dissertation, I investigated novel oxidative stress-mediated treatment approaches to target PDAC and GBM and to enhance immunogenicity by inducing immunogenic cell death (ICD). In the first part of this thesis (chapter 2), I reviewed the mechanistic responses of cancer cells towards different oxidative stress-inducing treatment strategies and their immunomodulating effects. The resulting literature demonstrated that different exogenous and endogenous ROS-inducing therapies show direct and indirect immunomodulating effects, which can be either immunostimulatory or immunosuppressive. One of the indirect immunostimulatory effects of the ROS-mediating therapies is the capacity of inducing immunogenic cell death (ICD) in tumor cells, which can increase the immunogenicity and consequently can trigger an antitumoral immune response. In chapter 3, I investigated a novel exogenous ROS-inducing treatment method, namely cold atmospheric plasma, to determine the therapeutic and ICD-inducing effects in PDAC, in vitro. I revealed that plasma-treated PBS (pPBS) has the potential to induce ICD in pancreatic cancer cells (PCCs) and to reduce the immunosuppressive tumor microenvironment (TME) by attacking the tumor supportive pancreatic stellate cells (PSCs). Although the cell death induced in PSCs was non-immunogenic as seen by the lack of danger-associated molecular patterns (DAMPs) emission and DC activation, I showed that pPBS could disrupt the physical barrier and lower the immunosuppressive secretion profile (lower TGF-β) of PSCs. In contrast, DAMPs were released by PCCs after treatment with pPBS which resulted in activation and maturation of DCs and a more immunostimulatory secretion profile (higher TNF-α, IFN-γ). Hence, indirect plasma treatment via pPBS has the potential to enhance immunogenicity in PDAC by triggering ICD and by attacking the immunosuppressive PSCs. Tumor cells can evolve adaptation mechanisms to protect themselves against intrinsic oxidative stress by upregulation of pro-survival molecules and their antioxidant defense system to maintain the redox balance. As such, tumor cells can become resistant towards exogenous ROS-inducing therapies, like plasma. Dual targeting of the redox balance of tumor cells by increasing exogenous levels of ROS and inhibiting the antioxidant defense system can maximally exploit ROS-mediated cell death mechanisms as therapeutic anticancer strategy. In this regard, cold atmospheric plasma was combined with auranofin, a thioredoxin reductase inhibitor, in GBM (chapter 4). A synergistic effect was shown after this combination treatment in 2D and 3D, however, in 3D only high concentrations of auranofin synergized with plasma treatment. I confirmed a ROS-mediated response after combination treatment, which was able to induce distinct cell death mechanisms, specifically apoptosis and ferroptosis. Additionally, the auranofin and plasma combined treatment strategy induced cell death, which resulted in an increased release of DAMPs. Together with the observed DC maturation, these results indicates the potential increase in immunogenicity, though, the phagocytotic capacity of DCs was inhibited by auranofin. In chapter 5, I evaluated this promising oxidative stress combination therapy in GBM, in vivo. A decrease in tumor kinetics and an increased survival in GBM-bearing mice was observed when auranofin was sequentially combined with direct plasma treatment. No T cell infiltration was observed after auranofin monotherapy. However, further characterization of the TME after the combination therapy is necessary to provide more insight in the immunogenic effects in vivo. In conclusion, this PhD dissertation comprises novel and important therapeutic and immunogenic insights in cold atmospheric plasma and auranofin as promising oxidative stress-mediated treatment strategies for low immunogenic tumors, like PDAC and GBM. These preclinical results provide a solid basis for future research towards combinations with immunotherapeutic approaches.
Keywords: Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT); Center for Oncological Research (CORE)
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“Temperate bamboos in ornamental horticulture: differentiators and spillover effects into the 21st century”. Gielis J page 603 (2012).
Keywords: H3 Book chapter; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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Xiao Y (2017) Theoretical study of the optoelectronic properties of new type 2DEG materials : multilayer graphene and monolayer MoS2. 144 p
Keywords: Doctoral thesis; Condensed Matter Theory (CMT)
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Taghizadeh Sisakht E (2019) Tight-binding investigation of the electronic properties of phosphorene and phosphorene nanoribbons. 150 p
Abstract: abstract not available
Keywords: Doctoral thesis; Condensed Matter Theory (CMT)
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Nakhaee M (2020) Tight-binding model for two-dimensional materials. 139 p
Abstract: abstract not available
Keywords: Doctoral thesis; Condensed Matter Theory (CMT)
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“Titanium (germano-)silicides featuring 10-9 Ω.cm2 contact resistivity and improved compatibility to advanced CMOS technology”. Yu H, Schaekers M, Chew SA, Eyeraert J-L, Dabral A, Pourtois G, Horiguchi N, Mocuta D, Collaert N, De Meyer K, 2018 18th International Workshop On Junction Technology (iwjt) , 80 (2018)
Abstract: uIn this work, we discuss three novel Ti (germano-)silicidation techniques featuring respectively the pre-contact amorphization implantation (PCAI), the TiSi co-deposition, and Ti atomic layer deposition (ALD). All three techniques form TiSix(Ge-y) contacts with ultralow contact resistivity (rho(c)) of (1-3)x10(-9) Omega.cm(2) on both highly doped n-Si and p-SiGe substrates: these techniques meet rho(c) requirement of 5-14 nm CMOS technology and feature unified CMOS contact solutions. We further discuss the compatibility of these techniques to the realistic CMOS transistor fabrication.
Keywords: P1 Proceeding; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT)
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“Toward energy autarky : carbon redirection coupled with shortcut nitrogen processes”. De Clippeleir H, Vlaeminck SE, Courtens ENP, Jimenez J, Wadhawan T, Zhang Q page 129 (2015).
Keywords: H3 Book chapter; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Towards a geometrical theory of morphology and morphogenesis”. Gielis J, Ding Y, Shi P, (2016)
Keywords: P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Towards application of mainstream deammonification on municipal wastewater in warm and cold areas”. Mozo I, Lacoste L, aussenac J, De Cocker P, Vlaeminck SE, Sperandio M, Caligaris M, Graveleau L, Barillon B, Martin Ruel S, , 4 p.
T2 (2016)
Keywords: P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Towards application of mainstream deammonification on municipal wastewater in warm and cold areas”. Mozo I, Lacoste L, Aussenac J, De Cocker P, Vlaeminck SE, Sperandio M, Caligaris M, Barillon B, Martin Ruel S, , 4 p.
T2 (2016)
Keywords: P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Towards upgrading of wastewater resources to microbial protein : volatile fatty acids impacting growth kinetics and yield of purple bacteria”. Alloul A, Vlaeminck SE, , 2 p.
T2 (2017)
Keywords: P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Trace analysis of environmental samples by X-ray emission spectroscopy”. Van Grieken RE, LaBrecque JJ page 101 (1985).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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“Trace metals in the St-Louis aerosol”. Winchester JW, Meinert DL, Nelson JW, Johansson TB, Van Grieken RE, Orsini C, Kaufmann HC, Akselsson R page 385 (1975).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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“Transitioning from mesophilic to thermophilic nitrification: shaping a niche for archaeal ammonia oxidizers”. Vandekerckhove T, Courtens ENP, Prat D, Vilchez-Vargas R, Vital M, Pieper DH, Meerbergen K, Lievens B, Boon N, Vlaeminck SE, , 9 p.
T2 (2016)
Keywords: P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL)
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“Understanding ultrafine particles dynamics within a one km urban grid”. Mishra VK, Dons E, Panis LI, Frijns E, van Poppel M, Berghmans P, Bleux N, Wuyts K, Samson R, (2010)
Keywords: P3 Proceeding; Sustainable Energy, Air and Water Technology (DuEL)
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“Use of grazing emission XRF spectrometry for silicon wafer surface contamination measurements”. de Gendt S, Kenis K, Mertens PW, Heyns MM, Claes M, Van Grieken RE, Bailleul A, Knotter M, de Bokx PK, (1996)
Keywords: P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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Amiri-Aref M (2015) Utilization of magnetic nanoparticles and carbon nanotubes to fabrication electrochemical sensors for determination of some important biological and pharmaceutical compounds. 137 p
Keywords: Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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