“Laser microprobe mass analysis (LAMMA) to verify the aluminon staining of bone”. Verbueken AH, van de Vijver FL, Visser WJ, Van Grieken RE, de Broe ME, Stain technology 61, 287 (1986). http://doi.org/10.3109/10520298609109955
Abstract: Triammonium aurin tricarboxylate (aluminon) has been used to localize aluminum in 2 μm sections of undecalcified, methyl methacrylate embedded bone obtained from patients with terminal chronic renal failure. Aluminum appeared in four cases as bright red lines at the mineralized-bone boundary. In two cases, however, purplish lines were found and one patient showed red as well as purplish lines. Laser microprobe mass analysis (LAMMA) identified aluminum at the location of the red lines and both aluminum and iron at the purplish lines. Furthermore, both iron and aluminum were found in histiocytic bone marrow cells, which showed brownish aluminon staining. It appears that when aluminum and iron occur together, aluminon staining may yield aberrant results. This study shows that LAMMA can be used for the identification of elements sought by histochemical methods and thus permits the evaluation of their staining effects.
Keywords: A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
DOI: 10.3109/10520298609109955
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van de Vijver FL, Verbueken AH, Visser WJ, Van Grieken RE, de Broe ME (1984) Localisation of aluminium and iron by histochemical and laster microprobe mass analytical techniques in bone marrow cells of chronic hemodialysis patients. 837–838
Keywords: L1 Letter to the editor; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
DOI: 10.1136/JCP.37.7.837-B
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“Doped albumin : stndardization possibilities for LAMMA-analysis of thin freeze-dried cryosections of biological tissue”. Verbueken AH, Jacob WA, Frederik PM, Busing WM, Hersten RC, Van Grieken RE, Journal de physique 45, 561 (1984)
Keywords: A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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“Applications of laser microprobe mass analysis in medicine”. Verbueken AH, van de Vijver FL, de Broe ME, Van Grieken RE, CRC critical reviews in clinical laboratory sciences 24, 263 (1987)
Keywords: A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Correlation of serum aluminium values with tissue aluminium concentration”. de Broe ME, van de Vijver FL, Bekaert AB, d'Haese P, Paulus GJ, Visser WJ, Van Grieken R, de Wolff FA, Verbueken AH, Contributions to nephrology 38, 37 (1984)
Keywords: A1 Journal article; Pharmacology. Therapy; Pathophysiology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Localization of aluminum in tissues”. Verbueken AH, van de Vijver FL, Nouwen EJ, Van Grieken RE, de Broe ME, Contributions to nephrology 64, 124 (1988)
Keywords: A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Patterns of iron storage in patients with severe renal failure”. van de Vijver FL, Vanheule AO, Verbueken AH, Van Grieken R, d'Haese P, Visser WJ, Bekaert AB, Buyssens N, de Broe ME, Contributions to nephrology 38, 153 (1984)
Keywords: A1 Journal article; Pharmacology. Therapy; Pathophysiology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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van de Vijver FL, Verbueken AH, Van Grieken RE, de Broe ME, Visser WJ (1985) Laser microprobe mass analysis : a tool for evaluating histochemical staining of trace elements. 351–352
Keywords: L1 Letter to the editor; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Ultrastructural localization of aluminum in patients with dialysis-associated osteomalacia”. Verbueken AH, van de Vijver FL, Van Grieken RE, Paulus GJ, Visser WJ, d'Haese P, de Broe ME, Clinical chemistry : international journal of laboratory medicine and molecular diagnostics 30, 763 (1984)
Abstract: Using laser microprobe mass analysis, we studied the ultrastructural localization of aluminum in liver and bone tissue of chronic-hemodialysis patients with proven aluminum-induced osteomalacia. In the liver, aluminum was observed to be almost exclusively associated with iron. Detectable aluminum and large amounts of iron were found in lysosomes of both hepatocytes and Kupffer cells. In bone, aluminum was localized at the osteoid/calcified-bone interface and also was associated with iron in some cases.
Keywords: A1 Journal article; Pharmacology. Therapy; Pathophysiology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Laser microprobe mass analysis : a review of applications in the life sciences”. Verbueken AH, Bruynseels FJ, Van Grieken RE, Biomedical mass spectrometry 12, 438 (1985). http://doi.org/10.1002/BMS.1200120903
Abstract: The characteristics and analytical utility of laser microprobe mass analysis (LAMMA) are described and evaluated, and a short history of this recent microanalytical technique is presented. A review of the areas of application of LAMMA and related laser microprobes is presented with special emphasis on applications in the life sciences.
Keywords: A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
DOI: 10.1002/BMS.1200120903
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“Laser microprobe mass spectrometry of platinum in dog kidney after cisplatin adminstration”. Verbueken AH, Van Grieken RE, Paulus GJ, Verpooten GA, de Broe ME, Biomedical mass spectrometry 11, 159 (1984). http://doi.org/10.1002/BMS.1200110404
Abstract: By means of laser microprobe mass analysis (LAMMA) platinum was detected in the renal proximal tubular cells of a dog that had been intravenously adminstered the antitumor drug cisplatin (5 mg per kg body weight). No definite subcellular localization of the heavy metal was obtained. Sample prparation and analytical features are examined to increase spatial resolution of analysis while maintaining sufficient detection efficiency. The LAMMA method is destructive, but the amount and type of evaporated material can readily be determined when using LAMMA in combination with transmission electron microscopy. Instrumental optimization and standardization of mass signals is possible by using platinum-loaded, ion chelating resin beads embedded and sectioned with the tissue.
Keywords: A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
DOI: 10.1002/BMS.1200110404
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“Use of laser microprobe mass analysis (LAMMA) for localizing multiple elements in soft and hard tissues”. Verbueken AH, van de Vijver FL, Visser WJ, Roels F, Van Grieken R, de Broe ME, Biological trace element research 13, 397 (1987). http://doi.org/10.1007/BF02796651
Abstract: The potential of laser microprobe mass analysis (LAMMA) as a sensitive microanalytical technique was explored in applications relevant to nephrology. Aluminum and associated elements, such as iron, were localized in fresh tissue biopsies obtained from uremic patients treatment by chronic hemodialysis. The LAMMA was applied to serum, liver, bone, and parathyroid glands of such patients. In addition, we used LAMMA to evaluate the specificity and sensitivity of routine histochemistry, in particular on human bone sections stained by the aluminon method. The high, multielemental sensitivity and molecular microprobe potential of LAMMA established important advantages over other microchemical methods forin situ analysis at the micron level in histological sections.
Keywords: A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
DOI: 10.1007/BF02796651
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“Laser microprobe mass spectrometric identification of cyclosporine-induced intrarenal microliths in rat”. Verbueken AH, Van Grieken RE, Verpooten GA, de Broe ME, Wedeen RP, Biological mass spectrometry 21, 590 (1992). http://doi.org/10.1002/BMS.1200211111
Keywords: A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
DOI: 10.1002/BMS.1200211111
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“Embedded ion exchange beads as standards for laser microprobe mass analysis of biological specimens”. Verbueken AH, Van Grieken RE, Paulus GJ, De Bruijn WC, Analytical chemistry 56, 1362 (1984). http://doi.org/10.1021/AC00272A036
Keywords: A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
DOI: 10.1021/AC00272A036
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“Identification of inorganic and organic microliths in kidney sections by laser microprobe mass spectrometry”. Verbueken AH, Van Grieken RE, de Broe ME, Wedeen RP, Analytica chimica acta 195, 97 (1987). http://doi.org/10.1016/S0003-2670(00)85653-6
Abstract: Laser microprobe mass spectrometry is used to identify intrarenal microliths; they appear to consist of either oxalate, urate or phosphate. Crystalline and amorphous deposits in rat and human kidney are pin-pointed by the laser beam and their chemical composition determined by mass spectrometry. The method has the potential for wide application in the identification of single organic, inorganic or combination crystals in histological sections.
Keywords: A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
DOI: 10.1016/S0003-2670(00)85653-6
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“Laser microprobe mass analysis (LAMMA) to study lead intoxication at the subcellular level”. Vandeputte DF, Verbueken AH, Jacob WA, Van Grieken RE, Acta pharmacologica et toxicologica 59, 617 (1986). http://doi.org/10.1111/J.1600-0773.1986.TB02840.X
Keywords: A3 Journal article; Pharmacology. Therapy; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
DOI: 10.1111/J.1600-0773.1986.TB02840.X
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“Application of laser microprobe mass analysis (LAMMA) to problems in nephrology”. Verbueken AH, Van de Vyver FL, Visser WJ, de Broe ME, Van Grieken RE page 987 (1986).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Evaluation of different techniques used to determine aluminium in patients with chronic renal failure”. Visser WJ, Van de Vyver FL, Verbueken AH, d'Haese P, Bekaert AB, Van Grieken RE, Duursma SA, de Broe ME, (1985)
Keywords: P3 Proceeding; Pathophysiology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“LAMMA in nephrotoxicity studies”. Verbueken AH, Paulus GJ, Van de Vyver FL, Verpooten GA, Visser WJ, de Broe ME, Van Grieken RE, (1984)
Keywords: P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Laser microprobe mass analysis (LAMMA) in nephrological investigations”. Verbueken AH, Van de Vyver FL, Paulus GJ, Visser WJ, Verpooten GA, de Broe ME, Van Grieken RE page 375 (1984).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“Laser microprobe mass analysis (LAMMA) of parathyroid glands from dialysis patients”. Verbueken AH, Van de Vyver FL, Nouwen EJ, Roels F, de Broe ME, Van Grieken RE page 443 (1987).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP)
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“A microanalytical study of green and necrotic needle tissue”. Goossenaerts CH, Verbueken AH, Jacob WA, Van Praag HJ, Van Grieken RE page 224 (1987).
Keywords: H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
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