Records |
Author |
Shaw, P. |
Title |
Dual action of reactive species as signal and stress agents in plasma medicine : combined computational and experimental research |
Type |
Doctoral thesis |
Year |
2021 |
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191 p. |
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Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT); Center for Oncological Research (CORE) |
Abstract |
Reactive oxygen and nitrogen species (RONS) generated by cold atmospheric plasma (CAP) can activate discrete signaling transduction pathways or disrupt redox cellular homeostasis, depending on their concentration. This makes that CAP possesses therapeutic potential towards wound healing, cancer, and other diseases. In order to effectively use CAP in the clinic, a clear understanding of the interaction of RONS with biomolecules (lipids, proteins and nucleic acids) from the atomic to the macro scale, and their biological significance, is needed. In this work, I have therefore studied the dual role of CAP-derived RONS, i.e., (i) in the signaling pathways involved in wound healing, and (ii) in their reaction with biomolecules to cause oxidation-mediated damage. I performed computer simulations to provide fundamental insight about the occurring processes that are difficult or even impossible to obtain experimentally. Furthermore, next to computational studies, I used both 2D and 3D tissue cultures. 3D model allows proliferation in a more physiologically relevant geometry that stimulates the production of extracellular matrix proteins. I investigated the treatment of human gingival fibroblasts with low doses of CAP-generated RONS. This treatment demonstrated that it can inhibit colony formation but does not induce cell death, induce the expression of metalloprotease proteins, induce extracellular matrix degradation, and promote cell migration, which could result in enhanced wound healing. In contrast, at high concentrations, RONS can disrupt the cell membrane integrity and induce cancer cell death through oxidative stress-mediated pathways. I discovered how oxidation of the cell membrane (lipid-peroxidation) can facilitate the access of a drug (Melittin) into cancer cells, and in this way, reduce the required therapeutic dose of Melittin in melanoma and breast cancer cells (demonstrated using in vitro, in ovo and in silico approaches). Furthermore, I studied how excessive lipid-oxidation in chemoresistant pancreatic cancer cells promotes ferroptotic cell death. This was due to the stimulation of the iron-dependent Fenton reaction by targeting a redox specific signaling network. However, upon oxidative stress, cells protect themselves via a sophisticated intracellular antioxidant system that involves the regulation of glutathione/glutathione peroxidase 4 (lipid repair enzyme). Cancer cells exhibited increased levels of intracellular RONS due to their hyper metabolism, leading to high expression of anti-oxidant systems. I therefore focus on the effect of reactive species on the intracellular anti-oxidant system and corresponding DNA damages in both temozolomide-sensitive as well as temozolomide-resistant glioblastoma spheroids, in a 3-dimensional tumor model with a more complex tumor microenvironment than cell monolayers. |
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Most recent IF: NA |
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UA @ admin @ c:irua:183751 |
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7828 |
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Author |
Reniers, G.L.L.; Sörensen, K.; Vrancken, K. |
Title |
Editorial introduction |
Type |
H1 Book chapter |
Year |
2013 |
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1-6
T2 - Management principles of sustainable indu |
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H1 Book chapter; Engineering Management (ENM); Sustainable Energy, Air and Water Technology (DuEL) |
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9783527649488 |
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UA @ admin @ c:irua:107601 |
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7833 |
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Author |
Keppens, E.; Roekens, E.; Van Grieken, R. |
Title |
Effect of pollution on sandy limestones of a historical cathedral in Belgium |
Type |
P3 Proceeding |
Year |
1985 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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UA @ admin @ c:irua:117499 |
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7838 |
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Author |
Leysen, L.; Roekens, E.; Van Grieken, R. |
Title |
Effecten van luchtverontreiniging op historische gebouwen |
Type |
P3 Proceeding |
Year |
1987 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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UA @ admin @ c:irua:117518 |
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7839 |
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Bernardi, A.; Becherini, F.; Kontozova, V.; Godoi, R.H.M.; Van Grieken, R.; Deutsch, F. |
Title |
Effects of air pollution and microclimate on stained glass windows: prliminary results in the Sainte Chapelle (Paris) |
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H3 Book chapter |
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2004 |
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133-140
T2 - Air pollution and cultural heritage / |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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UA @ admin @ c:irua:48940 |
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7843 |
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Van Grieken, R.; Vleugels, G.; Sweevers, E.; Dewolfs, R. |
Title |
Effects of air pollution on historic buildings and monuments (1986-1990): scientific basis for conservation: analytical study of the weathering of building stones under field-exposure conditions |
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A3 Journal article |
Year |
1994 |
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European cultural heritage newsletter on research |
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8 |
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2 |
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2-7 |
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A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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UA @ admin @ c:irua:55573 |
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7844 |
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Author |
Torfs, K.; Van Grieken, R. |
Title |
Effects of marine spray and air pollution on monuments in the Mediterranean coastal environment |
Type |
H3 Book chapter |
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1996 |
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170-174
T2 - Cultural research in Europe 1996 / Ha |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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UA @ admin @ c:irua:14680 |
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7848 |
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Author |
De Vis, K.; Jembrih-Simbürger, D.; Schalm, O.; Schreiner, M.; Caen, J. |
Title |
Einfluss verschiedener Silbersalze auf die Farbintensität von Silbergelb : analytische Untersuchungen |
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A2 Journal article |
Year |
2002 |
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Zeitschrift für Kunsttechnologie und Konservierung |
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16 |
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1 |
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147-157 |
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A2 Journal article; Art; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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0931-7198 |
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no |
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UA @ admin @ c:irua:107748 |
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7855 |
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Author |
Lou, W.-K. |
Title |
The electrical properties of low low dimensional topological insulators |
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Doctoral thesis |
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2012 |
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Pages |
186 p. |
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Doctoral thesis; Condensed Matter Theory (CMT) |
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no |
Call Number |
UA @ admin @ c:irua:158894 |
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7858 |
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Author |
Bia, P.; Caratelli, D.; Mescia, L.; Gielis, J. |
Title |
Electromagnetic characterization of supershaped lens antennas for high-frequency applications |
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H1 Book chapter |
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2013 |
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1679-1682
T2 - Proceedings of the 43rd European Mi |
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H1 Book chapter; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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000330768700424 |
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978-2-87487-031-6 |
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UA library record; WoS full record; WoS citing articles |
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no |
Call Number |
UA @ admin @ c:irua:110954 |
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7865 |
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Author |
Xhoffer, C.; Jacob, W.; Van Grieken, R.; Broekaert, J.A.C.; Buseck, P. |
Title |
Electron energy-loss spectroscopy and its application to individual particle analysis |
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P3 Proceeding |
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1992 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:2862 |
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7868 |
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Storms, H.; Van Dyck, P.; Van Grieken, R.; Maenhaut, W. |
Title |
Electron microprobe observations of recrystallization affecting PIXE-analysis of marine aerosol deposits |
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A1 Journal article |
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1985 |
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Journal of trace and microprobe techniques |
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2 |
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103-117 |
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A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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0733-4680; 1532-2270 |
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no |
Call Number |
UA @ admin @ c:irua:116718 |
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7871 |
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Author |
Leysen, L.A.; De Waele, J.K.; Roekens, E.J.; Van Grieken, R.E. |
Title |
Electron probe micro-analysis and laser microprobe mass analysis of material, leached from a limestone cathedral |
Type |
A1 Journal article |
Year |
1987 |
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Scanning microscopy |
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1 |
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Pages |
1617-1630 |
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A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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0891-7035 |
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UA @ admin @ c:irua:116794 |
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7872 |
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Author |
Hoornaert, S.; Treiger, B.; Van Grieken, R.; Valkovic, V. |
Title |
Electron probe X-ray microanalysis for the assessment of homogeneity of candidate reference materials at the nanogram level |
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H3 Book chapter |
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1996 |
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29-49b
T2 - Reference materials for microanalytica |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:14681 |
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7874 |
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Author |
Rahemi, V. |
Title |
Electrosensing applications by using titania as a support for bio(inspired) molecules |
Type |
Doctoral thesis |
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2018 |
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133 p. |
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Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA @ admin @ c:irua:152884 |
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7877 |
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Johansson, T.B.; Nelson, J.W.; Van Grieken, R.E.; Winchester, J.W. |
Title |
Elemental analysis of aerosol-size fractions by proton-induced X-ray-emission |
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A1 Journal article |
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1973 |
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Transactions of the American Nuclear Society |
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17 |
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Nov |
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103-103 |
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A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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A1973R161300114 |
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0003-018x |
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UA @ admin @ c:irua:113643 |
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7880 |
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Author |
Smekens, A.; Knupfer, M.; Berghmans, P.; Van Grieken, R. |
Title |
The elemental composition and microstructure of soot emitted by different sources |
Type |
A1 Journal article |
Year |
2000 |
Publication |
Journal of aerosol science |
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31 |
Issue |
S1 |
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917-918 |
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A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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0021-8502; 1879-1964 |
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UA @ admin @ c:irua:31647 |
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7887 |
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Author |
Vargas Paredes, A.A. |
Title |
Emergent phenomena in superconductors in presence of intraband and cross-band pairing |
Type |
Doctoral thesis |
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2020 |
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142 p. |
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Doctoral thesis; Condensed Matter Theory (CMT) |
Abstract |
In this thesis we investigate the emergence of new phenomena in multigap superconductors and multicomponent Ginzburg-Landau theories in the presence of intraband and cross-band pairing. The first part contains a review of emergent phenomena in superconductors with only intraband pairing, in particular the mechanism behind gap resonances which are accompanied by Higgs and Leggett modes. Then we study the gap resonances induced by two-dimensional quantum confinement and describe its spatial profile using the Bogoliubov-de Gennes equations. In the second part we describe the conditions where the cross-band pair formation is feasible. Using the formalism of Green functions we obtain the equations governing the interplay between intraband and cross-band pairing. Also, we derived the Ginzburg-Landau equations considering both intraband and cross-band pairing. Finally, we describe the crossover between the intraband-dominated and crossband-dominated regimes. These two are delimited by a tendency towards a gapless state. When a magnetic field is applied close to the gapless state, we found new arrangements of vortices like square lattices, stripes, labyrinths or of vortex clusters. The experimental signatures and consequences of crosspairing are discussed for MgB2 and Ba0.6K0.4Fe2As2. |
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Most recent IF: NA |
Call Number |
UA @ admin @ c:irua:165865 |
Serial |
7899 |
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Author |
Seuntjens, D.; Carvajal Arroyo, J.M.; Molina, J.; Boon, N.; Vlaeminck, S.E. |
Title |
Enabling partial nitritation/anammox on pre-treated sewage with IFAS : aeration and floc SRT control strategies limit nitrate production |
Type |
P3 Proceeding |
Year |
2017 |
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Pages |
3 p.
T2 - 5th IWA Benelux Young Water Professional |
Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
Call Number |
UA @ admin @ c:irua:151116 |
Serial |
7901 |
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Author |
Muia, L.M.; Van Grieken, R. |
Title |
Energy-dispersive X-ray fluorescence analysis of geological materials in borax beads using Tertian's binary coefficient approach combined with internal standard addition |
Type |
A1 Journal article |
Year |
1991 |
Publication |
X-ray spectrometry |
Abbreviated Journal |
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Volume |
20 |
Issue |
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Pages |
179-183 |
Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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ISSN |
0049-8246 |
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no |
Call Number |
UA @ admin @ c:irua:662 |
Serial |
7903 |
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Author |
Van Grieken, R.; Robberecht, H.; Shani, J.; Van Dyck, P.; Vos, L. |
Title |
Energy-dispersive X-ray fluorescence for direct trace analysis of biomedical and environmental samples |
Type |
H3 Book chapter |
Year |
1982 |
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Volume |
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Issue |
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Pages |
159-178
T2 - X-ray fluorescence (XRF and PIXE) in |
Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
Call Number |
UA @ admin @ c:irua:117485 |
Serial |
7904 |
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Author |
Vanderborght, B.; Van Grieken, R. |
Title |
Energy-dispersive X-ray fluorescence for trace metals analysis of water |
Type |
H3 Book chapter |
Year |
1975 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
1-9
T2 - Nuclear techniques in environmental resea |
Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
Call Number |
UA @ admin @ c:irua:117461 |
Serial |
7905 |
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Author |
Seuntjens, D.; Bundervoet, B.L.M.; Mollen, H.; De Mulder, C.; Wypkema, E.; Verliefde, A.; Nopens, I.; Colsen, J.G.M.; Vlaeminck, S.E. |
Title |
Energy efficient treatment of A-stage effluent : pilot-scale experiences with short-cut nitrogen removal |
Type |
P3 Proceeding |
Year |
2015 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
10 p.
T2 - IWA Nutrient Removal and Recovery 2015: |
Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
Call Number |
UA @ admin @ c:irua:151146 |
Serial |
7909 |
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Author |
Vanderborght, B.M.; Van Grieken, R.E. |
Title |
Enrichment of trace metals in water by adsorption on activated carbon |
Type |
A1 Journal article |
Year |
1977 |
Publication |
Analytical chemistry |
Abbreviated Journal |
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Volume |
49 |
Issue |
2 |
Pages |
311-316 |
Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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ISSN |
0003-2700; 5206-882x |
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no |
Call Number |
UA @ admin @ c:irua:116513 |
Serial |
7923 |
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Author |
Van Grieken, R.; Bresseleers, K.; Smits, J.; Vanderborght, B.; Vanderstappen, M. |
Title |
Enrichment procedures for water analysis by X-ray energy spectrometry |
Type |
P3 Proceeding |
Year |
1976 |
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Pages |
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Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
Call Number |
UA @ admin @ c:irua:113634 |
Serial |
7924 |
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Author |
Alexiades, V.; Autrique, D. |
Title |
Enthalpy model for heating, melting, and vaporization in laser ablation |
Type |
A1 Journal article |
Year |
2010 |
Publication |
Electronic journal of differential equations |
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Pages |
1-13 |
Keywords |
A1 Journal article; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT) |
Abstract |
Laser ablation is used in a growing number of applications in various areas including medicine, archaeology, chemistry, environmental and materials sciences. In this work the heat transfer and phase change phenomena during nanosecond laser ablation of a copper (Cu) target in a helium (He) background gas at atmospheric pressure are presented. An enthalpy model is outlined, which accounts for heating, melting, and vaporization of the target. As far as we know, this is the first model that connects the thermodynamics and underlying kinetics of this challenging phase change problem in a selfconsistent way. |
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000455668500001 |
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ISSN |
1072-6691 |
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no |
Call Number |
UA @ admin @ c:irua:190550 |
Serial |
7925 |
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Author |
Xhoffer, C.; Van Grieken, R. |
Title |
Environmental aerosol characterization by single particle analysis techniques |
Type |
H3 Book chapter |
Year |
1993 |
Publication |
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Volume |
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Issue |
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Pages |
207-245
T2 - Environmental particles; 2 / Buffle, |
Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
Call Number |
UA @ admin @ c:irua:6267 |
Serial |
7926 |
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Author |
Delalieux, F.; Cardell, C.; Todorov, V.; Dekov, V.; Van Grieken, R. |
Title |
Environmental conditions controlling the chemical weathering of the Madara Horseman monument, NE Bulgaria |
Type |
A1 Journal article |
Year |
2001 |
Publication |
Journal of cultural heritage |
Abbreviated Journal |
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Volume |
2 |
Issue |
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Pages |
43-54 |
Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Edition |
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ISSN |
1296-2074 |
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no |
Call Number |
UA @ admin @ c:irua:32822 |
Serial |
7927 |
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Author |
Camuffo, D.; Van Grieken, R.; Busse, H.-J.; Sturaro, G.; Valentino, A.; Bernardi, A.; Blades, N.; Shooter, D.; Gysels, K.; Deutsch, F.; Wieser, M.; Kim, O.; Ulrych, U. |
Title |
Environmental monitoring in four European museums |
Type |
A1 Journal article |
Year |
2001 |
Publication |
Atmospheric environment : an international journal |
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Volume |
35 |
Issue |
S1 |
Pages |
S127-S140 |
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A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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000169404000015 |
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Edition |
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ISSN |
1352-2310 |
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no |
Call Number |
UA @ admin @ c:irua:36082 |
Serial |
7928 |
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Author |
Jambers, W.; Van Grieken, R.E. |
Title |
Environmental problems |
Type |
H3 Book chapter |
Year |
1997 |
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Issue |
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Pages |
803-819
T2 - Handbook of microscopy: applications |
Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
Call Number |
UA @ admin @ c:irua:18789 |
Serial |
7929 |
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