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Author Daems, E.
Title Shaping up oligonucleotides : aptamer-target recognition investigated by native mass spectrometry Type Doctoral thesis
Year 2021 Publication Abbreviated Journal
Volume Issue Pages 235 p.
Keywords (up) Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract Aptamers are short, synthetic DNA or RNA molecules that are characterized by a specific 3D conformation which enables specific target recognition. Aptamers are promising tools in many application fields from sensing to therapeutics. One of the major challenges in the aptamer field is understanding the relationship between the sequence and what determines the higher-order structure and specific interactions with targets. Therefore, this PhD thesis focuses on the use of different mass spectrometry (MS) based approaches to characterize aptamers and their interactions. Several of these approaches are already widely applied to study other biomolecules, such as proteins, but are still largely unexplored for aptamers and oligonucleotides in general. A first focus was put on obtaining information on the higher-order structure and conformational stability of aptamers using a combination of MS and with ion mobility (IM) spectrometry by performing collision-induced unfolding (CIU) experiments. CIU was shown to hold great promise to analyze the conformational dynamics and gas-phase stabilities of aptamers. Next, the capabilities and limitations of native IM-MS for the analysis of noncovalent interactions of aptamers were demonstrated. The conformational behavior and interactions of cocaine-binding aptamers were studied and it was found that relative binding affinities of aptamers that only differ slightly in sequence and structure can be determined using native MS. Moreover, native IM-MS allowed the detection of small conformational changes upon binding of a target, which were found to be dependent on the binding mode of the aptamer. An adaptive binding mechanism was suggested for flexible aptamers that require more reorganization upon binding. In the final part of this thesis, the importance of thoroughly characterizing and validating aptamer-target interactions before using them in an application was emphasized. Moreover, the gathered insights were applied in our own development of a proof-of-concept aptamer-based sensor. This was shown by investigating the interactions of ampicillin aptamers which were found to not bind the target they were selected for in the first place. A multi-analytical approach combining complementary techniques was used for this purpose since no single technique is generally applicable to characterize all aptamers and their interactions and to obtain a comprehensive picture of the aptamer-target interactions. Furthermore, such multi-analytical approach was used to characterize a testosterone-binding aptamer while developing an aptamer-based electrochemiluminescent sensing strategy for this target. This shows the importance of native MS, in combination with other techniques, to thoroughly understand the aptamer-target interactions in the development of a designed application.
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ admin @ c:irua:178116 Serial 8517
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Author Piñera Hernández, I.
Title Simulation of atom displacements induced by photons and electrons in solids Type Doctoral thesis
Year 2014 Publication Abbreviated Journal
Volume Issue Pages 137 p.
Keywords (up) Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:116687 Serial 8526
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Author Amiri-Aref, M.
Title Utilization of magnetic nanoparticles and carbon nanotubes to fabrication electrochemical sensors for determination of some important biological and pharmaceutical compounds Type Doctoral thesis
Year 2015 Publication Abbreviated Journal
Volume Issue Pages 137 p.
Keywords (up) Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:128299 Serial 8727
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Author Sleegers, N.
Title Cephalosporin antibiotics : electrochemical fingerprints and redox pathways investigated by mass spectral analysis Type Doctoral thesis
Year 2021 Publication Abbreviated Journal
Volume Issue Pages 208 p.
Keywords (up) Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Antwerp Electrochemical and Analytical Sciences Lab (A-Sense Lab)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Editor
Language Wos Publication Date
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ admin @ c:irua:181014 Serial 7588
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Author Li, B.
Title Aharonov-Bohm effect in semiconductor quantum rings Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:99488 Serial 85
Permanent link to this record
 

 
Author Komendová, L.
Title Characteristic length scales and vortex interactions in two-component superconducting systems Type Doctoral thesis
Year 2013 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:112085 Serial 312
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Author Carrillo Nuñez, H.
Title Combining the modified local density approach with variational calculus : a flexible tandem for studying electron transport in nano-devices Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:109447 Serial 405
Permanent link to this record
 

 
Author Zarenia, M.
Title Confined states in mono- and bi-layer grapheme nanostructures Type Doctoral thesis
Year 2013 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:108668 Serial 485
Permanent link to this record
 

 
Author Kapra, A.
Title Controlling the flux dynamics in superconductors by nanostructured magnetic arrays Type Doctoral thesis
Year 2013 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:114596 Serial 508
Permanent link to this record
 

 
Author Lin, N.
Title Dynamics of interacting clusters in low-dimensional superconductors Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:102534 Serial 776
Permanent link to this record
 

 
Author Zhang, L.
Title Effects of quantum confinement in nanoscale superconductors : from electronic density of states to vortex matter Type Doctoral thesis
Year 2015 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:126085 Serial 870
Permanent link to this record
 

 
Author Masir, M.R.
Title Electronic properties of graphene in inhomogeneous magnetic fields Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:98178 Serial 1001
Permanent link to this record
 

 
Author Kishore, V.V.R.
Title Electronic structure of core-shell nanowires Type Doctoral thesis
Year 2013 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:105035 Serial 1013
Permanent link to this record
 

 
Author Sivek, J.
Title First-principles characterization and functionalization of graphene-like materials Type Doctoral thesis
Year 2015 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:125632 Serial 1204
Permanent link to this record
 

 
Author Dixit, H.
Title First-principles electronic structure calculations of transparent conducting oxide materials Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:99490 Serial 1209
Permanent link to this record
 

 
Author Amini, M.
Title First-principles study of defects in transparent conducting oxide materials Type Doctoral thesis
Year 2014 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:113390 Serial 1216
Permanent link to this record
 

 
Author Xu, B.
Title Magnetic, calorimetric and electronic properties of vortex states in (3D) mesoscopic superconductors Type Doctoral thesis
Year 2011 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:91833 Serial 1863
Permanent link to this record
 

 
Author Grujić, M.M.
Title Manifestations of intrinsic and induced magnetic properties of graphene nanostructures Type Doctoral thesis
Year 2015 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher University of Antwerp, Faculty of Sciences, Department of Physics Place of Publication Antwerp Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:126212 Serial 1939
Permanent link to this record
 

 
Author Nasr Esfahani, D.
Title Strongly correlated electronic systems : influence of electric field and doping Type Doctoral thesis
Year 2014 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:118557 Serial 3186
Permanent link to this record
 

 
Author Galván Moya, J.E.
Title Structural properties of classical quasi-one-dimensional crystals and three-dimensional clusters Type Doctoral thesis
Year 2014 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:117413 Serial 3256
Permanent link to this record
 

 
Author Muñoz, W.A.
Title Superconducting correlations in single and multilayer graphene Type Doctoral thesis
Year 2014 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:120588 Serial 3350
Permanent link to this record
 

 
Author Chen, Y.
Title Superconductivity in nanofilms and nanocylinders Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:99024 Serial 3373
Permanent link to this record
 

 
Author da Costa, D.R.
Title Transport and confinement in monolayer and bilayer graphene nanostructures with different edges, interfaces and potentials Type Doctoral thesis
Year 2015 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:125274 Serial 3722
Permanent link to this record
 

 
Author Barbier, M.
Title Transport properties of nanostructures and superlattices on single-layer and bilayer graphene Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:100632 Serial 3728
Permanent link to this record
 

 
Author Singh, S.K.
Title Vibrational properties of graphene nano-flakes and thermo-mechanical properties of graphene-like materials Type Doctoral thesis
Year 2014 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:116622 Serial 3845
Permanent link to this record
 

 
Author Geurts, R.
Title Vortex-antivortex molecules in mesoscopic quantum systems Type Doctoral thesis
Year 2011 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:96434 Serial 3856
Permanent link to this record
 

 
Author Zhao, H.
Title Vortex matter in superconductors with competing interactions : formation of vortex patterns and vortex dynamics Type Doctoral thesis
Year 2012 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date 0000-00-00
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:100630 Serial 3874
Permanent link to this record
 

 
Author Schoeters, B.
Title An ab initio study of the properties of doped semiconducting nanwires Type Doctoral thesis
Year 2015 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:128354 Serial 4133
Permanent link to this record
 

 
Author Orlova, N.
Title Emergent phenomena in superconductors and superfluids with multicomponent quantum condensates Type Doctoral thesis
Year 2016 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:134094 Serial 4172
Permanent link to this record
 

 
Author Van Duppen, B.
Title Plasmonics in graphene and related materials Type Doctoral thesis
Year 2016 Publication Abbreviated Journal
Volume Issue Pages
Keywords (up) Doctoral thesis; Condensed Matter Theory (CMT)
Abstract
Address
Corporate Author Thesis
Publisher Place of Publication Antwerpen Editor
Language Wos Publication Date
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN ISBN Additional Links UA library record
Impact Factor Times cited Open Access
Notes Approved Most recent IF: NA
Call Number UA @ lucian @ c:irua:133554 Serial 4226
Permanent link to this record