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Author Mescia, L.; Chiapperino, M.A.; Bia, P.; Gielis, J.; Caratelli, D.
Title Modeling of electroporation induced by pulsed electric fields in irregularly shaped cells Type A1 Journal article
Year 2018 Publication IEEE transactions on biomedical engineering Abbreviated Journal
Volume 65 Issue 2 Pages 414-423
Keywords A1 Journal article; Sustainable Energy, Air and Water Technology (DuEL)
Abstract During the past decades, the poration of cell membrane induced by pulsed electric fields has been widely investigated. Since the basic mechanisms of this process have not yet been fully clarified, many research activities are focused on the development of suitable theoretical and numerical models. To this end, a nonlinear, nonlocal, dispersive, and space-time numerical algorithm has been developed and adopted to evaluate the transmembrane voltage and pore density along the perimeter of realistic irregularly shaped cells. The presented model is based on the Maxwell's equations and the asymptotic Smoluchowski's equation describing the pore dynamics. The dielectric dispersion of the media forming the cell has been modeled by using a general multirelaxation Debye-based formulation. The irregular shape of the cell is described by using the Gielis' superformula. Different test cases pertaining to red blood cells, muscular cells, cell in mitosis phase, and cancer-like cell have been investigated. For each type of cell, the influence of the relevant shape, the dielectric properties, and the external electric pulse characteristics on the electroporation process has been analyzed. The numerical results demonstrate that the proposed model is an efficient numerical tool to study the electroporation problem in arbitrary-shaped cells.
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Corporate Author Thesis
Publisher Place of Publication Editor (up)
Language Wos 000422914700018 Publication Date 2017-11-13
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0018-9294 ISBN Additional Links UA library record; WoS full record; WoS citing articles
Impact Factor Times cited Open Access
Notes Approved no
Call Number UA @ admin @ c:irua:148417 Serial 8264
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