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| Author |
Adams, F.; Vincze, L.; Vekemans, B. |
| Title |
Synchrotron radiation for microscopic X-ray fluorescence analysis |
Type |
H3 Book chapter |
| Year |
2004 |
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343-353
T2 - X-ray spectrometry: recent technologi |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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UA @ admin @ c:irua:46499 |
Serial |
8634 |
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| Author |
Van Loenhout, J. |
| Title |
Targeting pancreatic ductal adenocarcinoma and glioblastoma with oxidative stress-mediated treatment strategies : focus on tumor cell death and modulation of the tumor microenvironment |
Type |
Doctoral thesis |
| Year |
2021 |
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167 p. |
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Doctoral thesis; Plasma Lab for Applications in Sustainability and Medicine – Antwerp (PLASMANT); Center for Oncological Research (CORE) |
| Abstract |
Pancreatic ductal adenocarcinoma (PDAC) and glioblastoma multiforme (GBM) are two of the most malignant solid tumor types with poor survival rates, which underscore the urgency of novel and efficacious treatment strategies. Within the last decade, immunotherapy has been established as a breakthrough in cancer therapy. This mainly has been driven by the clinical data and approval associated with several immune checkpoint inhibitors (e.g. anti-CTLA-4 and anti-PD-1/L1). Despite the clinical benefit in specific tumor types, these inhibitors have not yet fulfilled their promise in low immunogenic tumors such as PDAC and GBM. Oxidative stress in cancer cells due to elevated reactive oxygen species (ROS) and an inability to balance intracellular redox state has recently been highlighted as promising target for anticancer treatment strategies with possible immunogenic effects. In this PhD dissertation, I investigated novel oxidative stress-mediated treatment approaches to target PDAC and GBM and to enhance immunogenicity by inducing immunogenic cell death (ICD). In the first part of this thesis (chapter 2), I reviewed the mechanistic responses of cancer cells towards different oxidative stress-inducing treatment strategies and their immunomodulating effects. The resulting literature demonstrated that different exogenous and endogenous ROS-inducing therapies show direct and indirect immunomodulating effects, which can be either immunostimulatory or immunosuppressive. One of the indirect immunostimulatory effects of the ROS-mediating therapies is the capacity of inducing immunogenic cell death (ICD) in tumor cells, which can increase the immunogenicity and consequently can trigger an antitumoral immune response. In chapter 3, I investigated a novel exogenous ROS-inducing treatment method, namely cold atmospheric plasma, to determine the therapeutic and ICD-inducing effects in PDAC, in vitro. I revealed that plasma-treated PBS (pPBS) has the potential to induce ICD in pancreatic cancer cells (PCCs) and to reduce the immunosuppressive tumor microenvironment (TME) by attacking the tumor supportive pancreatic stellate cells (PSCs). Although the cell death induced in PSCs was non-immunogenic as seen by the lack of danger-associated molecular patterns (DAMPs) emission and DC activation, I showed that pPBS could disrupt the physical barrier and lower the immunosuppressive secretion profile (lower TGF-β) of PSCs. In contrast, DAMPs were released by PCCs after treatment with pPBS which resulted in activation and maturation of DCs and a more immunostimulatory secretion profile (higher TNF-α, IFN-γ). Hence, indirect plasma treatment via pPBS has the potential to enhance immunogenicity in PDAC by triggering ICD and by attacking the immunosuppressive PSCs. Tumor cells can evolve adaptation mechanisms to protect themselves against intrinsic oxidative stress by upregulation of pro-survival molecules and their antioxidant defense system to maintain the redox balance. As such, tumor cells can become resistant towards exogenous ROS-inducing therapies, like plasma. Dual targeting of the redox balance of tumor cells by increasing exogenous levels of ROS and inhibiting the antioxidant defense system can maximally exploit ROS-mediated cell death mechanisms as therapeutic anticancer strategy. In this regard, cold atmospheric plasma was combined with auranofin, a thioredoxin reductase inhibitor, in GBM (chapter 4). A synergistic effect was shown after this combination treatment in 2D and 3D, however, in 3D only high concentrations of auranofin synergized with plasma treatment. I confirmed a ROS-mediated response after combination treatment, which was able to induce distinct cell death mechanisms, specifically apoptosis and ferroptosis. Additionally, the auranofin and plasma combined treatment strategy induced cell death, which resulted in an increased release of DAMPs. Together with the observed DC maturation, these results indicates the potential increase in immunogenicity, though, the phagocytotic capacity of DCs was inhibited by auranofin. In chapter 5, I evaluated this promising oxidative stress combination therapy in GBM, in vivo. A decrease in tumor kinetics and an increased survival in GBM-bearing mice was observed when auranofin was sequentially combined with direct plasma treatment. No T cell infiltration was observed after auranofin monotherapy. However, further characterization of the TME after the combination therapy is necessary to provide more insight in the immunogenic effects in vivo. In conclusion, this PhD dissertation comprises novel and important therapeutic and immunogenic insights in cold atmospheric plasma and auranofin as promising oxidative stress-mediated treatment strategies for low immunogenic tumors, like PDAC and GBM. These preclinical results provide a solid basis for future research towards combinations with immunotherapeutic approaches. |
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Most recent IF: NA |
| Call Number |
UA @ admin @ c:irua:181309 |
Serial |
8643 |
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| Author |
Gielis, J. |
| Title |
Temperate bamboos in ornamental horticulture: differentiators and spillover effects into the 21st century |
Type |
H3 Book chapter |
| Year |
2012 |
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603-623
T2 - Proceedings of the 9th World Bamboo C |
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H3 Book chapter; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
| Call Number |
UA @ admin @ c:irua:97755 |
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8644 |
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| Author |
Xiao, Y. |
| Title |
Theoretical study of the optoelectronic properties of new type 2DEG materials : multilayer graphene and monolayer MoS2 |
Type |
Doctoral thesis |
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2017 |
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144 p. |
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Doctoral thesis; Condensed Matter Theory (CMT) |
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no |
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UA @ admin @ c:irua:144948 |
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8661 |
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| Author |
Taghizadeh Sisakht, E. |
| Title |
Tight-binding investigation of the electronic properties of phosphorene and phosphorene nanoribbons |
Type |
Doctoral thesis |
| Year |
2019 |
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150 p. |
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Doctoral thesis; Condensed Matter Theory (CMT) |
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abstract not available |
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no |
| Call Number |
UA @ admin @ c:irua:166195 |
Serial |
8670 |
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| Author |
Nakhaee, M. |
| Title |
Tight-binding model for two-dimensional materials |
Type |
Doctoral thesis |
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2020 |
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139 p. |
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Doctoral thesis; Condensed Matter Theory (CMT) |
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abstract not available |
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Most recent IF: NA |
| Call Number |
UA @ admin @ c:irua:166134 |
Serial |
8671 |
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| Author |
De Clippeleir, H.; Vlaeminck, S.E.; Courtens, E.N.P.; Jimenez, J.; Wadhawan, T.; Zhang, Q. |
| Title |
Toward energy autarky : carbon redirection coupled with shortcut nitrogen processes |
Type |
H3 Book chapter |
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2015 |
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Pages |
129-150
T2 - Shortcut nitrogen removal : nitrite s |
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H3 Book chapter; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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978-1-57278-313-3 |
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no |
| Call Number |
UA @ admin @ c:irua:130470 |
Serial |
8676 |
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| Author |
Gielis, J.; Ding, Y.; Shi, P. |
| Title |
Towards a geometrical theory of morphology and morphogenesis |
Type |
P3 Proceeding |
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2016 |
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P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
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UA @ admin @ c:irua:144548 |
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8677 |
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Mozo, I.; Lacoste, L.; aussenac, J.; De Cocker, P.; Vlaeminck, S.E.; Sperandio, M.; Caligaris, M.; Graveleau, L.; Barillon, B.; Martin Ruel, S. |
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Towards application of mainstream deammonification on municipal wastewater in warm and cold areas |
Type |
P3 Proceeding |
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2016 |
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4 p.
T2 - World Cities Summit, Singapore Internati |
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P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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UA @ admin @ c:irua:151124 |
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8678 |
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Mozo, I.; Lacoste, L.; Aussenac, J.; De Cocker, P.; Vlaeminck, S.E.; Sperandio, M.; Caligaris, M.; Barillon, B.; Martin Ruel, S. |
| Title |
Towards application of mainstream deammonification on municipal wastewater in warm and cold areas |
Type |
P3 Proceeding |
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2016 |
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Pages |
4 p.
T2 - WEF/IWA Nutrient Removal and Recovery Co |
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P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
| Call Number |
UA @ admin @ c:irua:151136 |
Serial |
8679 |
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Alloul, A.; Vlaeminck, S.E. |
| Title |
Towards upgrading of wastewater resources to microbial protein : volatile fatty acids impacting growth kinetics and yield of purple bacteria |
Type |
P3 Proceeding |
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2017 |
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2 p.
T2 - 5th IWA Benelux Young Water Professional |
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P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
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UA @ admin @ c:irua:151115 |
Serial |
8683 |
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| Author |
Van Grieken, R.E.; LaBrecque, J.J. |
| Title |
Trace analysis of environmental samples by X-ray emission spectroscopy |
Type |
H3 Book chapter |
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1985 |
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101-183
T2 - Trace analysis : vol. 4 / Lawrence, J |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
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UA @ admin @ c:irua:117495 |
Serial |
8686 |
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Winchester, J.W.; Meinert, D.L.; Nelson, J.W.; Johansson, T.B.; Van Grieken, R.E.; Orsini, C.; Kaufmann, H.C.; Akselsson, R. |
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Trace metals in the St-Louis aerosol |
Type |
H3 Book chapter |
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1975 |
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385-394
T2 - Nuclear techniques in environmental r |
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H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
| Call Number |
UA @ admin @ c:irua:117459 |
Serial |
8694 |
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Vandekerckhove, T.; Courtens, E.N.P.; Prat, D.; Vilchez-Vargas, R.; Vital, M.; Pieper, D.H.; Meerbergen, K.; Lievens, B.; Boon, N.; Vlaeminck, S.E. |
| Title |
Transitioning from mesophilic to thermophilic nitrification: shaping a niche for archaeal ammonia oxidizers |
Type |
P3 Proceeding |
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2016 |
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Pages |
9 p.
T2 - WEF/IWA Nutrient Removal and Recovery Co |
| Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
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UA @ admin @ c:irua:151126 |
Serial |
8697 |
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Mishra, V.K.; Dons, E.; Panis, L.I.; Frijns, E.; van Poppel, M.; Berghmans, P.; Bleux, N.; Wuyts, K.; Samson, R. |
| Title |
Understanding ultrafine particles dynamics within a one km urban grid |
Type |
P3 Proceeding |
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2010 |
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P3 Proceeding; Sustainable Energy, Air and Water Technology (DuEL) |
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no |
| Call Number |
UA @ admin @ c:irua:88671 |
Serial |
8709 |
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de Gendt, S.; Kenis, K.; Mertens, P.W.; Heyns, M.M.; Claes, M.; Van Grieken, R.E.; Bailleul, A.; Knotter, M.; de Bokx, P.K. |
| Title |
Use of grazing emission XRF spectrometry for silicon wafer surface contamination measurements |
Type |
P3 Proceeding |
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1996 |
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P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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| Call Number |
UA @ admin @ c:irua:14679 |
Serial |
8720 |
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Amiri-Aref, M. |
| Title |
Utilization of magnetic nanoparticles and carbon nanotubes to fabrication electrochemical sensors for determination of some important biological and pharmaceutical compounds |
Type |
Doctoral thesis |
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2015 |
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137 p. |
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Doctoral thesis; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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no |
| Call Number |
UA @ admin @ c:irua:128299 |
Serial |
8727 |
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Vanmeert, F.; Van der Snickt, G.; Legrand, S.; Janssens, K. |
| Title |
Velázquez? A portrait of Pope Innocent X : an X-ray imaging investigation (II) |
Type |
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2019 |
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Pages |
132-141
T2 - Velázquez : Anregungen, Vorschläge, L |
| Keywords |
H3 Book chapter; Art; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
| Abstract |
Encompassing a broad spectrum of methodological approaches and aims, the scholars contributing to this volume offer renewed perspectives on the multifaceted oeuvre of Diego Velázquez. The seventeenth-century artist’s exceptional religious works as well as his numerous portraits are examined within the social and historical context of Velázquez’s milieu which included both the Spanish court as well as circles comprising important intellectual figures of his time. Following a close investigation of his works, which also includes the results of recent technological examinations on his paintings, the contributors to this volume offer new, exciting findings and discussions on the inspirations, sources and possible intentions of Velázquez. |
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978-3-99020-155-8 |
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no |
| Call Number |
UA @ admin @ c:irua:190783 |
Serial |
8736 |
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| Author |
Lindeboom, R.E.F.; Clauwaert, P.; Alloul, A.; Coessens, W.; Christiaens, M.; Vanoppen, M.; Rabaey, K.; Verliefde, A.R.D.; Vlaeminck, S.E. |
| Title |
Water and nutrient recovery from combined urine and grey water treatment in Space |
Type |
P3 Proceeding |
| Year |
2015 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
3 p.
T2 - IWA Resource Recovery Conference, 30 Aug |
| Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:151143 |
Serial |
8747 |
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| Author |
Han, M.; Seuntjens, D.; Al-Omari, A.; Takacs, I.; Meerburg, F.; Murthy, S.; Vlaeminck, S.E.; De Clippeleir, H. |
| Title |
Water and process parameters as controllers for the ammonia to nitrite oxidation rate ratio in activated sludge |
Type |
P3 Proceeding |
| Year |
2017 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
3 p.
T2 - IWA 2017 Conference on Sustainable Waste |
| Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:151110 |
Serial |
8748 |
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| |
| Author |
de Paepe, J.; Lindeboom, R.E.F.; Vanoppen, M.; Alonso Farinas, B.; Coessens, W.; Abbas, A.; Christiaens, M.; Dotremont, C.; Beckers, H.; Lamaze, B.; Demey, D.; Rabaey, K.; Clauwaert, P.; Verliefde, A.R.D.; Vlaeminck, S.E. |
| Title |
Water treatment unit breadboard : ground test facility for the recycling of urine and shower water for one astronaut |
Type |
P3 Proceeding |
| Year |
2017 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
2 p.
T2 - 5th IWA Benelux Young Water Professional |
| Keywords |
P3 Proceeding; Engineering sciences. Technology; Sustainable Energy, Air and Water Technology (DuEL) |
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UA library record |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:151114 |
Serial |
8749 |
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| |
| Author |
Delalieux, F.; Sweevers, H.; Van Grieken, R. |
| Title |
Weathering mechanism of Pentelic marble under ambient atmospheric conditions derived from runoff studies |
Type |
P3 Proceeding |
| Year |
1997 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
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| Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA library record |
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| Notes |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:18791 |
Serial |
8751 |
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| Author |
Vleugels, G.; Van Grieken, R. |
| Title |
Weathering of bare and treated limestones under ambient conditions using runoff water analysis and microanalysis |
Type |
P3 Proceeding |
| Year |
1992 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
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| Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Edition |
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Additional Links |
UA library record |
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Open Access |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:2865 |
Serial |
8752 |
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| Author |
Roekens, E.; Van Raemdonck, C.; Leysen, L.; Chakravorty, R.; Van Grieken, R. |
| Title |
Weathering products and surface recession rates for sandy limestones exposed to air pollution |
Type |
H3 Book chapter |
| Year |
1987 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
707-714
T2 - Acid rain : scientific and technical |
| Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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UA library record |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:117536 |
Serial |
8756 |
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| Author |
Van Grieken, R. |
| Title |
Working close to the detection limits: XRF |
Type |
Minutes and reports |
| Year |
1998 |
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Abbreviated Journal |
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Issue |
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Pages |
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| Keywords |
Minutes and reports; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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Additional Links |
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| Notes |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:20973 |
Serial |
8761 |
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| Author |
Samek, L.; Worobiec, A.; Van Grieken, R.; van Meel, K.; Kontozova, V.; Karaszkiewicz, P.; Wiłkojć, E. |
| Title |
Wpływ zwiedzajacych na zanieczyszczenia wnetrz muzealnych |
Type |
H3 Book chapter |
| Year |
2007 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
209-218
T2 - Konserwacja zapobiegawcza w muzeach |
| Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP) |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:67628 |
Serial |
8762 |
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| Author |
Injuk, J.; Van Grieken, R.E. |
| Title |
X-ray fluorescence |
Type |
H3 Book chapter |
| Year |
2001 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
151-178
T2 - Non-destructive elemental analysis / |
| Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
| Abstract |
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Additional Links |
UA library record |
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| Notes |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:34107 |
Serial |
8764 |
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| Author |
Margu'i', E.; Queralt, I.; Van Grieken, R. |
| Title |
X-ray fluorescence analysis, sample preparation for |
Type |
H1 Book chapter |
| Year |
2009 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
1-20
T2 - Sncyclopedia of analytical chemistry / M |
| Keywords |
H1 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
| Abstract |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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ISBN |
978-0-471-97670-7 |
Additional Links |
UA library record |
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|
Open Access |
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| Notes |
|
Approved |
no |
| Call Number |
UA @ admin @ c:irua:81641 |
Serial |
8765 |
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| |
| Author |
Vincze, L.; Vekemans, B.; Szaloki, I.; Brenker, F.E.; Falkenberg, G.; Rickers, K.; Aerts, K.; Van Grieken, R.; Adams, F. |
| Title |
X-ray fluorescence microtomography and polycapillary based confocal imaging using synchrotron radiation |
Type |
P1 Proceeding |
| Year |
2004 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
220-231
T2 - 4th Conference on Developments in X-R |
| Keywords |
P1 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
| Abstract |
Ibis work illustrates the development of X-ray fluorescence tomography and polycapillary based confocal imaging towards a three-dimensional (313), quantitative analytical method with lateral resolution levels down to the 2-20 mum scale. Detailed analytical characterization is given for polycapillary based confocal XRF imaging, which is a new variant of the 3D micro-XRF technique. Applications for 2D/3D micro-XR-F are illustrated for the analysis of biological (zooplankton) and geological samples (microscopic inclusions in natural diamonds and fluid inclusions in quartz). Based on confocal imaging, fully three-dimensional distributions of trace elements could be obtained, representing a significant generalization of the regular 2D scanning technique for micro-XRF spectroscopy. The experimental work described in this paper has been carried out at the ESRF ID18F microfluorescence end-station and at HASYLAB Beam Line L. |
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Wos |
000225665000023 |
Publication Date |
2004-11-02 |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
0-8194-5473-7 |
ISBN |
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Additional Links |
UA library record; WoS full record; WoS citing articles |
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| Notes |
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Approved |
no |
| Call Number |
UA @ admin @ c:irua:94812 |
Serial |
8767 |
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| Author |
Marguí, E.; Van Grieken, R. |
| Title |
X-ray fluorescence spectrometry and related techniques : an introduction |
Type |
MA3 Book as author |
| Year |
2013 |
Publication |
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Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
148 p. |
| Keywords |
MA3 Book as author; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
| Abstract |
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Editor |
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Wos |
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Series Title |
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Abbreviated Series Title |
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| Series Volume |
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Series Issue |
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Edition |
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| ISSN |
|
ISBN |
978-1-60650-391-1 |
Additional Links |
UA library record |
| Impact Factor |
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Times cited |
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Open Access |
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| Notes |
|
Approved |
no |
| Call Number |
UA @ admin @ c:irua:106179 |
Serial |
8768 |
| Permanent link to this record |
