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González-Rubio, G.; Mosquera, J.; Kumar, V.; Pedrazo-Tardajos, A.; Llombart, P.; Solís, D.M.; Lobato, I.; Noya, E.G.; Guerrero-Martínez, A.; Taboada, J.M.; Obelleiro, F.; MacDowell, L.G.; Bals, S.; Liz-Marzán, L.M. |
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Title |
Micelle-directed chiral seeded growth on anisotropic gold nanocrystals |
Type |
A1 Journal article |
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Year  |
2020 |
Publication |
Science |
Abbreviated Journal |
Science |
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Volume |
368 |
Issue |
368 |
Pages |
1472-1477 |
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Keywords |
A1 Journal article; Engineering sciences. Technology; Electron microscopy for materials research (EMAT) |
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Abstract |
Surfactant-assisted seeded growth of metal nanoparticles (NPs) can be engineered to produce anisotropic gold nanocrystals with high chiroptical activity through the templating effect of chiral micelles formed in the presence of dissymmetric cosurfactants. Mixed micelles adsorb on gold nanorods, forming quasihelical patterns that direct seeded growth into NPs with pronounced morphological and optical handedness. Sharp chiral wrinkles lead to chiral plasmon modes with high dissymmetry factors (~0.20). Through variation of the dimensions of chiral wrinkles, the chiroptical properties can be tuned within the visible and near-infrared electromagnetic spectrum. The micelle-directed mechanism allows extension to other systems, such as the seeded growth of chiral platinum shells on gold nanorods. This approach provides a reproducible, simple, and scalable method toward the fabrication of NPs with high chiral optical activity. |
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Wos |
000545264600040 |
Publication Date |
2020-06-26 |
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ISSN |
0036-8075 |
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Additional Links |
UA library record; WoS full record; WoS citing articles |
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Impact Factor |
56.9 |
Times cited |
187 |
Open Access |
OpenAccess |
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Notes |
L.M.L.-M. acknowledges funding from the European Research Council (ERC AdG No. 787510). G.G.-R. and J.M. thanks the Spanish MICIU for FPI (BES-2014-068972) and Juan de la Cierva-fellowships (FJCI-2015-25080). S.B., L.M.L.-M., V.K, and A.P.- T. acknowledge financial support from the European Commission under the Horizon 2020 Programme by means of the grant agreement No. 731019 (EUSMI) and the ERC Consolidator Grant No. 815128 (REALNANO). J.M.T and F.O acknowledge financial support from the Spanish MICIU (Grants TEC2017-85376-C2-1-R, TEC2017-85376-C2-2-R), as well as from the ERDF and the Galician Regional Government as part of the agreement for funding the Atlantic Research Center for Information and Communication Technologies (AtlantTIC). AG-M acknowledges financial support from the Spanish MICIU (Grant RTI2018-095844-BI00), EGN and LGM acknowledge funds from the Spanish MICIU (Grant No. FIS2017- 89361-C3-2-P), as well as the use of the Mare-Nostrum supercomputer and the technical support provided by Barcelona Supercomputing Center from the Spanish Network of Supercomputing (Grants QCM-2018-3-0039 and QCM-2019-1-0038). This work was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State 13 Research Agency – Grant No. MDM-2017-0720.; sygma |
Approved |
Most recent IF: 56.9; 2020 IF: 37.205 |
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Call Number |
EMAT @ emat @c:irua:170137 |
Serial |
6391 |
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Author |
Kumar, J.; Eraña, H.; López-Martínez, E.; Claes, N.; Martín, V.F.; Solís, D.M.; Bals, S.; Cortajarena, A.L.; Castilla, J.; Liz-Marzán, L.M. |
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Title |
Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality |
Type |
A1 Journal article |
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Year |
2018 |
Publication |
Proceedings of the National Academy of Sciences of the United States of America |
Abbreviated Journal |
P Natl Acad Sci Usa |
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Volume |
115 |
Issue |
115 |
Pages |
3225-3230 |
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Keywords |
A1 Journal article; Engineering sciences. Technology; Electron microscopy for materials research (EMAT) |
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Abstract |
Amyloid fibrils, which are closely associated with various neurodegenerative
diseases, are the final products in many protein aggregation pathways. The identification of fibrils at low concentration is, therefore, pivotal in disease diagnosis and development of therapeutic strategies. We report a methodology for the specific identification of amyloid fibrils using chiroptical effects in plasmonic nanoparticles. The formation of amyloid fibrils based on α-synuclein was probed using gold nanorods, which showed no
apparent interaction with monomeric proteins but effective adsorption onto fibril structures via noncovalent interactions. The amyloid structure drives a helical nanorod arrangement, resulting in intense optical activity at the surface plasmon resonance wavelengths. This sensing technique was successfully applied to human brain homogenates of patients affected by Parkinson’s disease,
wherein protein fibrils related to the disease were identified through chiral signals from Au nanorods in the visible and near IR, whereas healthy brain samples did not exhibit any meaningful optical activity. The technique was additionally extended to the specific detection of infectious amyloids formed by prion proteins, thereby confirming the wide potential of the technique. The intense chiral response driven by strong dipolar coupling in helical Au nanorod arrangements allowed us to detect amyloid fibrils down to nanomolar concentrations. |
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000428382400032 |
Publication Date |
2018-03-12 |
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ISSN |
0027-8424 |
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Additional Links |
UA library record; WoS full record; WoS citing articles |
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Impact Factor |
9.661 |
Times cited |
187 |
Open Access |
OpenAccess |
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Notes |
We thank Prof. Dr. J.-P. Timmermans and the Antwerp Centre of Advanced Microscopy for providing access to the Tecnai G2 Spirit BioTWIN TEM. We also thank the Basque Biobank (Basque Foundation for Health Innovation and Research, BIOEF) for providing us with Parkinson’s disease-affected brain samples. J.K. acknowledges financial support from the European Commission under Marie Sklodowska-Curie Program H2020- MSCA-IF-2015708321. S.B. and A.L.C. acknowledge European Research Council Grants 335078 COLOURATOM and 648071 ProNANO. S.B. and L.M.L.-M. acknowledge funding from European Commission Grant EUSMI 731019. A.L.C., J.C., and L.M.L.-M. acknowledge funding from Spanish Ministry of Economy and Competitiveness (MINECO) Grants MAT2013-46101- R, AGL2015-65046-C2-1-R, and BIO2016-77367-C2-1-R. (ROMEO:yellow; preprint:; postprint:restricted ; pdfversion:restricted); saraecas; ECASSara; |
Approved |
Most recent IF: 9.661 |
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Call Number |
EMAT @ emat @c:irua:150355UA @ admin @ c:irua:150355 |
Serial |
4918 |
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