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Verbueken, A.H.; Van Grieken, R.E.; Paulus, G.J.; Verpooten, G.A.; de Broe, M.E. |
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Title |
Laser microprobe mass spectrometry of platinum in dog kidney after cisplatin adminstration |
Type |
A3 Journal article |
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Year  |
1984 |
Publication |
Biomedical mass spectrometry |
Abbreviated Journal |
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Volume |
11 |
Issue |
4 |
Pages |
159-163 |
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Keywords |
A3 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP) |
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Abstract |
By means of laser microprobe mass analysis (LAMMA) platinum was detected in the renal proximal tubular cells of a dog that had been intravenously adminstered the antitumor drug cisplatin (5 mg per kg body weight). No definite subcellular localization of the heavy metal was obtained. Sample prparation and analytical features are examined to increase spatial resolution of analysis while maintaining sufficient detection efficiency. The LAMMA method is destructive, but the amount and type of evaporated material can readily be determined when using LAMMA in combination with transmission electron microscopy. Instrumental optimization and standardization of mass signals is possible by using platinum-loaded, ion chelating resin beads embedded and sectioned with the tissue. |
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Publication Date |
2005-05-28 |
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ISSN |
0306-042x |
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UA library record |
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Call Number |
UA @ admin @ c:irua:116712 |
Serial |
8165 |
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Author |
Verbueken, A.H.; Van Grieken, R.E.; Paulus, G.J.; De Bruijn, W.C. |
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Title |
Embedded ion exchange beads as standards for laser microprobe mass analysis of biological specimens |
Type |
A1 Journal article |
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Year |
1984 |
Publication |
Analytical chemistry |
Abbreviated Journal |
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Volume |
56 |
Issue |
8 |
Pages |
1362-1370 |
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Keywords |
A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) |
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A1984SX51800045 |
Publication Date |
2005-03-08 |
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ISSN |
0003-2700; 5206-882x |
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Additional Links |
UA library record; WoS full record; WoS citing articles |
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Call Number |
UA @ admin @ c:irua:116520 |
Serial |
7898 |
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Author |
Verbueken, A.H.; Van de Vyver, F.L.; Paulus, G.J.; Visser, W.J.; Verpooten, G.A.; de Broe, M.E.; Van Grieken, R.E. |
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Title |
Laser microprobe mass analysis (LAMMA) in nephrological investigations |
Type |
H3 Book chapter |
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Year |
1984 |
Publication |
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Abbreviated Journal |
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Volume |
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Issue |
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Pages |
375-382
T2 - Trace element analytical chemistry in |
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Keywords |
H3 Book chapter; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP) |
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Call Number |
UA @ admin @ c:irua:117493 |
Serial |
8156 |
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Author |
Verbueken, A.H.; van de Vijver, F.L.; Van Grieken, R.E.; Paulus, G.J.; Visser, W.J.; d'Haese, P.; de Broe, M.E. |
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Title |
Ultrastructural localization of aluminum in patients with dialysis-associated osteomalacia |
Type |
A1 Journal article |
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Year |
1984 |
Publication |
Clinical chemistry : international journal of laboratory medicine and molecular diagnostics |
Abbreviated Journal |
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Volume |
30 |
Issue |
5 |
Pages |
763-768 |
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Keywords |
A1 Journal article; Pharmacology. Therapy; Pathophysiology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP) |
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Abstract |
Using laser microprobe mass analysis, we studied the ultrastructural localization of aluminum in liver and bone tissue of chronic-hemodialysis patients with proven aluminum-induced osteomalacia. In the liver, aluminum was observed to be almost exclusively associated with iron. Detectable aluminum and large amounts of iron were found in lysosomes of both hepatocytes and Kupffer cells. In bone, aluminum was localized at the osteoid/calcified-bone interface and also was associated with iron in some cases. |
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A1984SR66500043 |
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ISSN |
0009-9147; 1530-8561 |
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UA library record; WoS full record; WoS citing articles |
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Call Number |
UA @ admin @ c:irua:116713 |
Serial |
8703 |
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Author |
Verbueken, A.H.; Paulus, G.J.; Van de Vyver, F.L.; Verpooten, G.A.; Visser, W.J.; de Broe, M.E.; Van Grieken, R.E. |
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Title |
LAMMA in nephrotoxicity studies |
Type |
P3 Proceeding |
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Year |
1984 |
Publication |
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Abbreviated Journal |
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Issue |
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Pages |
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Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP) |
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Call Number |
UA @ admin @ c:irua:117492 |
Serial |
8150 |
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Author |
de Broe, M.E.; van de Vijver, F.L.; Bekaert, A.B.; d'Haese, P.; Paulus, G.J.; Visser, W.J.; Van Grieken, R.; de Wolff, F.A.; Verbueken, A.H. |
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Title |
Correlation of serum aluminium values with tissue aluminium concentration |
Type |
A1 Journal article |
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Year |
1984 |
Publication |
Contributions to nephrology |
Abbreviated Journal |
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Volume |
38 |
Issue |
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Pages |
37-46 |
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Keywords |
A1 Journal article; Pharmacology. Therapy; Pathophysiology; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP) |
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0302-5144 |
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Call Number |
UA @ admin @ c:irua:116703 |
Serial |
7735 |
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Author |
Verbueken, A.; Paulus, G.; Van de Vyver, F.; Verpooten, G.; de Broe, M.; Van Grieken, R. |
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Title |
LAMMA : calibration and application to nephrotoxicology studies |
Type |
P3 Proceeding |
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Year |
1983 |
Publication |
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Abbreviated Journal |
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Keywords |
P3 Proceeding; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation); Laboratory Experimental Medicine and Pediatrics (LEMP) |
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Call Number |
UA @ admin @ c:irua:117491 |
Serial |
8149 |
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