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| Author | Pilehvar, S.; Jambrec, D.; Gebala, M.; Schuhmann, W.; De Wael, K. | ||||
| Title | Intercalation of proflavine in ssDNA aptamers : effect on binding of the specific target chloramphenicol | Type | A1 Journal article | ||
| Year | 2015 | Publication | Electroanalysis | Abbreviated Journal | Electroanal |
| Volume | 27 | Issue | 8 | Pages | 1836-1841 |
| Keywords | A1 Journal article; AXES (Antwerp X-ray Analysis, Electrochemistry and Speciation) | ||||
| Abstract | The structural modification of ssDNA-based aptamers upon specific binding of its target molecule leads to changes of the charge-transfer resistance (Rct) of a negatively-charged free-diffusing redox probe. The aptamer adopts a structure due to self-hybridization which is stabilized using profalvine as intercalator. The pre-organized aptamer structure is used to detect chloramphenicol (CAP) requiring a substantial change of the aptamer structure indicated by a CAP concentration dependent increase in the Rct values. Pre-incubation of the aptamer-modified electrode with an intercalator allows for the modulation of the aptamer/target interaction and hence for a modulation of the CAP-dependent variation of the Rct values. | ||||
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| Language | Wos | 000359737500006 | Publication Date | 2015-06-12 | |
| Series Editor | Series Title | Abbreviated Series Title | |||
| Series Volume | Series Issue | Edition | |||
| ISSN | 1040-0397 | ISBN | Additional Links | UA library record; WoS full record; WoS citing articles | |
| Impact Factor | 2.851 | Times cited | 5 | Open Access | |
| Notes | ; D. J., M. G., W. S. are grateful for financial support to the Deutsch-Israelische Projektkooperation (DIP) in the framework of the project “Nanoengineered optoelectronics with biomaterials and bioinspired assemblies” funded by the Deutsche Forschungsgemeinschaft. S. P. and K. D. W. are thankful to UA for DOCPRO financial support. ; | Approved | Most recent IF: 2.851; 2015 IF: 2.138 | ||
| Call Number | UA @ admin @ c:irua:126494 | Serial  |
5666 | ||
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